血栓形成是癌症患者死亡的主要原因。白藜芦醇抑制血小板活化，这是健康个体血栓形成的重要病理生理基础。然而，其对结肠癌患者的作用和作用机制仍不清楚。在这里，我们研究了白藜芦醇对结肠癌患者血小板粘附和聚集的影响。通过大量的体外和体内分析，包括流式细胞术、蛋白质印迹、ELISA、免疫荧光和结肠癌大鼠模型，我们证明白藜芦醇通过抑制 MAPK 磷酸化和激活环 GMP 来减少结肠癌患者的血栓形成/血管舒张剂刺激的磷蛋白途径。这些发现证明了白藜芦醇在减少结肠癌患者血栓形成方面的潜力，可用于开发针对这种疾病的新治疗策略。版权所有 © 2024。由 Elsevier Ltd 出版。

Thrombosis is the primary cause of death in patients with cancer. Resveratrol inhibits platelet activation, a crucial pathophysiological basis of thrombosis, in healthy individuals. However, its effects and mechanisms of action in patients with colon cancer remain unknown. Here, we investigated the effect of resveratrol on platelet adhesion and aggregation in patients with colon cancer. Through numerous in vitro and in vivo analyses, including flow cytometry, western blotting, ELISA, and immunofluorescence and colon cancer rat models, we demonstrated that resveratrol reduced thrombosis in patients with colon cancer by inhibiting the phosphorylation of the MAPK and activating the cyclic-GMP/vasodilator-stimulated phosphoprotein pathway. These findings demonstrate the potential of resveratrol in reducing thrombosis in patients with colon cancer and could be used to develop novel therapeutic strategies for this condition.Copyright © 2024. Published by Elsevier Ltd.