分析女性乳腺癌和妇科癌症 (FeBGC) 的全球负担、趋势和跨国不平等。基于人群的研究。数据来源于 2019 年全球疾病负担研究。诊断患有 FeBGC 的个人。年龄标准化死亡率 (ASMR) ）、年龄标准化伤残调整生命年 (DALY) 率 (ASDR) 及其 95% 不确定区间 (UI) 描述了负担。估计年度百分比变化 (EAPC) 及其年龄标准化率 (ASR) 的置信区间 (CI) 说明了趋势。使用不平等斜率指数（SII）和集中指数对社会不平等进行量化。主要结果指标是 FeBGC 的负担及其不平等随时间的趋势。2019 年，每 100 000 名女性的 ASDR 如下：乳腺癌：473.83（95% UI：437.30-510.51）、宫颈癌：210.64（95% UI：177.67-234.85）、卵巢癌：124.68（95% UI：109.13-138.67）和子宫癌：210.64（95% UI：177.67） -234.85）。 1990 年至 2019 年的每年趋势以 ASDR 的 EAPC 表示，其中： 乳腺癌：-0.51（95% CI：-0.57 至 -0.45）；宫颈癌：-0.95（95% CI：-0.99至-0.89）；卵巢癌：-0.08（95% CI：-0.12至-0.04）；子宫癌：-0.84（95% CI：-0.93 至 -0.75）。在社会不平等分析（1990-2019）中，乳腺癌的SII从689.26变为607.08，宫颈癌的SII从-226.66变为-239.92，卵巢癌的SII从222.45变为228.83，子宫癌的SII从74.61变为103.58。浓度指数值范围为0.2至0.4。1990年至2019年，全球FeBGCs负担呈下降趋势。社会人口指数（SDI）较高的国家或地区，乳腺癌、卵巢癌和子宫癌的DALYs负担较高，而SDI较低的人患宫颈癌的负担较重。这些不平等随着时间的推移而加剧。© 2024 John Wiley

To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs).Population-Based Study.Data sourced from the Global Burden of Disease Study 2019.Individuals diagnosed with FeBGCs.Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30-510.51), cervical cancer: 210.64 (95% UI: 177.67-234.85), ovarian cancer: 124.68 (95% UI: 109.13-138.67) and uterine cancer: 210.64 (95% UI: 177.67-234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: -0.51 (95% CI: -0.57 to -0.45); Cervical cancer: -0.95 (95% CI: -0.99 to -0.89); Ovarian cancer: -0.08 (95% CI: -0.12 to -0.04); and Uterine cancer: -0.84 (95% CI: -0.93 to -0.75). In the Social Inequalities Analysis (1990-2019) the SII changed from 689.26 to 607.08 for Breast, from -226.66 to -239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.© 2024 John Wiley & Sons Ltd.