个体的遗传指纹正在成为许多疾病和治疗相关因素的关键预测因子。药物代谢酶中的单核苷酸多态性 (SNP) 在个体暴露于恶性肿瘤相关风险中发挥着关键作用，例如黄曲霉毒素 B1 (AFB1) 诱发的肝细胞癌 (HCC)。本研究旨在回顾有关以下多态性的文献：存在于 CYP 酶中及其与 AFB1 诱导的 HCC 易感性的可能联系。使用一组与感兴趣的研究主题相关的关键词来搜索 Google Scholar 和 PubMed 数据库。过去十年的研究项目都包含在结果过滤器中。该研究涉及 HCC 患者以及 CYP 酶的多态性与 AFB1 诱导的 HCC 易感性之间的任何联系，包括较旧但重要的数据。 据报道，CYP1A2 和 CYP3A4 的变异会影响 AFB1 生物激活的速率和程度，从而影响个人罹患 HCC 的脆弱性。在 HCC 患者中，CYP 亚型的活性各不相同，据报道 CYP2C9、CYP2D6 和 CYP2E1 的活性增加，而 CYP1A2、CYP2C8 和 CYP2C19 的活性降低。已发现 HCC 患者的 CYP2D6*10 频率存在显着差异。 Rs2740574（在 CYP3A4*1B 中检测到的 CYP3A4 上游多态性）和 rs776746（影响 CYP3A5 RNA 剪接），两者都会影响 CYP3A 表达，从而影响 HCC 患者中 AFB1-环氧化物加合物的变异性。CYP1A2 是负责的主要酶在全球范围内形成有害的 AFBO。 CYP3A4、CYP3A5、CYP3A7、CYP2B7 和 CYP3A3 也参与 AFB1 对诱变代谢物的生物激活。人们认为CYP3A4是与AFB1代谢相互作用最多的蛋白质。CYP酶的多态性变体对AFB1诱导的HCC的易感性具有功能性影响。概述此类变化及其影响可能会为以更个性化的方式处理 HCC 提供更深入的见解，从而指导未来的风险评估、诊断和治疗。© 2024 Stichting 欧洲临床研究学会期刊基金会。约翰·威利出版

An individual's genetic fingerprint is emerging as a pivotal predictor of numerous disease- and treatment-related factors. Single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes play key roles in an individual's exposure to a malignancy-associated risk, such as Aflatoxin B1 (AFB1)-induced hepatocellular carcinoma (HCC).This study aimed at reviewing literature on the polymorphisms that exist in CYP enzymes and their possible link with susceptibility to AFB1-induced HCC.A set of keywords associated with the study subject of interest was used to search the Google Scholar and the PubMed database. The last ten years' worth of research projects were included in the results filter. The research involved HCC patients and any connection between polymorphic forms of CYP enzymes and their susceptibility to AFB1-induced HCC, including older but significant data.Variations in CYP1A2 and CYP3A4 were reported to impact the rate and magnitude of AFB1 bio-activation, thus influencing an individual's vulnerability to develop HCC. In HCC patients, the activity of CYP isoforms varies, where increased activity has been reported with CYP2C9, CYP2D6, and CYP2E1, while CYP1A2, CYP2C8, and CYP2C19 exhibit decreased activity. CYP2D6*10 frequency has been discovered to differ considerably in HCC patients. Rs2740574 (an upstream polymorphism in CYP3A4 as detected in CYP3A4*1B) and rs776746 (which affects CYP3A5 RNA splicing), both of which influence CYP3A expression, thus impacting the variability of AFB1-epoxide adducts in HCC patients.CYP1A2 is the primary enzyme accountable for the formation of harmful AFBO globally. CYP3A4, CYP3A5, CYP3A7, CYP2B7, and CYP3A3 are also implicated in the bio-activation of AFB1 to mutagenic metabolites. It is thought that CYP3A4 is the protein that interacts with AFB1 metabolism the most.Polymorphic variants of CYP enzymes have a functional impact on the susceptibility to AFB1-induced HCC. Outlining such variation and their implications may provide deeper insights into approaching HCC in a more personalized manner for guiding future risk-assessment, diagnosis, and treatment.© 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.