侵袭性曲霉菌病 (IA) 是儿童急性淋巴细胞白血病 (ALL) 和急性髓细胞白血病 (AML) 的一种潜在危及生命的并发症。我们对2000年以来0-17岁儿童急性白血病的研究进行了系统回顾和荟萃分析。研究结果按照系统评价和荟萃分析声明的首选报告项目进行报告。我们纳入了 24 项研究，涉及 3,661 名 ALL 患者和 1,728 名 AML 患者。各项研究中 IA 累积发生率各不相同（ALL 为 0%-10%，AML 为 0%-18%）。 ALL 中汇总的累积 IA 发生率估计为 3.2%（95% CI：1.8% - 5.8%），AML 中为 5.2%（95% CI：3.1% - 8.6%），相应的病死率为 13.3%（ 95% CI：6.3% - 25.9%）和 7.8%（95% CI：0.7% - 51.2%）。我们的分析强调了 IA 对儿童白血病的影响，强调需要制定儿童白血病 IA 的预防、早期检测和治疗策略。© 作者 2024。由牛津大学出版社代表《The Journal of 白血病杂志》出版儿科传染病协会。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

Invasive aspergillosis (IA) is a potentially life-threatening complication of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). We conducted a systematic review and meta-analyses of studies on acute leukemia in children aged 0-17 years since 2000. Findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We included 24 studies with 3,661 ALL patients and 1,728 AML patients. IA cumulative incidence varied (0%-10% for ALL and 0%-18% for AML) across the studies. Pooled cumulative IA incidences were estimated at 3.2% (95% CI: 1.8% - 5.8%) in ALL and 5.2% (95% CI: 3.1% - 8.6%) in AML, with corresponding case-fatality-rates of 13.3% (95% CI: 6.3% - 25.9%) and 7.8% (95% CI: 0.7% - 51.2%), respectively. Our analysis highlights the impact of IA in childhood leukemia, underscoring the need to address strategies for prevention, early detection, and treatment of IA in pediatric leukemia.© The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.