基于纳米技术的癌症治疗受到了相当大的关注，这些治疗通常使用载药纳米颗粒（NP）来靶向和破坏癌细胞。纳米技术与光动力疗法（PDT）相结合已在癌症治疗中显示出积极的效果。纳米技术与 PDT 相结合可有效靶向转移性癌细胞。纳米技术还可以通过在分子水平上靶向细胞来提高 PDT 的有效性。基于树枝状聚合物的纳米缀合物（DBN）具有高度稳定性和生物相容性，使其适合药物输送应用。此外，DBN 中的超支化结构能够负载疏水性化合物，如光敏剂 (PS) 和化疗药物，并将其有效地递送至肿瘤细胞。本综述主要关注 DBN 及其在癌症治疗中的潜在应用。我们讨论了 DBN 在肿瘤转移中的化学设计、作用机制和靶向效率、癌症治疗中的细胞内运输，以及 DBN 的生物相容性、生物降解性和清除特性。总的来说，这项研究将为 DBN 和 PDT 在癌症治疗中的应用提供最新的见解。

Nanotechnology-based cancer treatment has received considerable attention, and these treatments generally use drug-loaded nanoparticles (NPs) to target and destroy cancer cells. Nanotechnology combined with photodynamic therapy (PDT) has demonstrated positive outcomes in cancer therapy. Combining nanotechnology and PDT is effective in targeting metastatic cancer cells. Nanotechnology can also increase the effectiveness of PDT by targeting cells at a molecular level. Dendrimer-based nanoconjugates (DBNs) are highly stable and biocompatible, making them suitable for drug delivery applications. Moreover, the hyperbranched structures in DBNs have the capacity to load hydrophobic compounds, such as photosensitizers (PSs) and chemotherapy drugs, and deliver them efficiently to tumour cells. This review primarily focuses on DBNs and their potential applications in cancer treatment. We discuss the chemical design, mechanism of action, and targeting efficiency of DBNs in tumour metastasis, intracellular trafficking in cancer treatment, and DBNs' biocompatibility, biodegradability and clearance properties. Overall, this study will provide the most recent insights into the application of DBNs and PDT in cancer therapy.