铀天然存在于用于饮用的地下水中；然而，自然产生的浓度对健康的风险尚不确定。摄入铀后会引起放射性和化学毒性。当铀排泄到尿液中时，膀胱和肾脏会接受一定剂量的铀。在病例对照研究中调查饮用水中的铀与膀胱癌风险之间的关联。在密歇根州东南部 11 个县进行了一项基于人群的膀胱癌病例对照研究。共有411名病例和566名对照者提供了饮用水和脚趾甲样本，并回答了有关生活方式和居住史的问题。在饮用水和脚趾甲中测量了铀，并通过无条件逻辑回归模型评估了其与膀胱癌的关联。水中铀浓度中位数为0.12 μg L-1，最大值为4.99 μg L-1，脚趾甲中铀浓度中位数为0.0031 μg g-1。在调整后的回归模型中，建议对暴露于饮用水中铀上四分位数的人群（HR = 0.64，95% CI：0.43，0.96）和脚趾甲（HR 0.66；95% CI 0.45，0.96）有保护作用。 ）与最低四分位的那些相比。我们的目标是调查招募时对家庭住所饮用水源的额外调整，以解决潜在的选择偏差和混淆饮用水铀（HR = 0.68，95% CI：0.44，1.05）和脚趾甲铀零值的衰减结果（HR = 0.80，95% CI：0.53，1.20）。这项病例对照研究表明，饮用水或脚趾甲中发现的铀不会增加膀胱癌的风险。版权所有 © 2024 健康物理学会。

Uranium is naturally occurring in groundwater used for drinking; however, health risks from naturally occurring concentrations are uncertain. Uranium can cause both radiological and chemical toxicity following ingestion. Bladder and kidneys receive a dose when uranium is excreted into the urine. Investigate the association between uranium in drinking water and bladder cancer risk in a case-control study. A population-based bladder cancer case-control study was conducted in 11 counties of southeastern Michigan. A total of 411 cases and 566 controls provided drinking water and toenail samples and answered questions about lifestyle and residential history. Uranium was measured in drinking water and toenails, and its association with bladder cancer was assessed via unconditional logistic regression models. Median uranium concentration in water was 0.12 μg L-1, with a maximum of 4.99 μg L-1, and median uranium concentration in toenails was 0.0031 μg g-1. In adjusted regression models, there was a suggestion of a protective effect among those exposed to the upper quartile of uranium in drinking water (HR = 0.64, 95% CI: 0.43, 0.96) and toenails (HR 0.66; 95% CI 0.45, 0.96) compared to those in the lowest quartile. Our objective is to investigate additional adjustment of drinking water source at home residence at time of recruitment to address potential selection bias and confounding attenuated results toward the null for drinking water uranium (HR = 0.68, 95% CI: 0.44, 1.05) and toenail uranium (HR = 0.80, 95% CI: 0.53, 1.20). This case-control study showed no increased risk of bladder cancer associated with uranium found in drinking water or toenails.Copyright © 2024 Health Physics Society.