HLA-DP 允许错配的方向性改善了 HCT 中急性白血病和 MDS 的风险预测。
Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS.
发表日期：2024 Aug 05
作者：
Esteban Arrieta-Bolaños, Lars L J van der Burg, Tobias Gedde-Dahl, Marie Robin, Urpu Salmenniemi, Nicolaus Kröger, Ibrahim Yakoub-Agha, Anne Huynh, Charles R Crawley, Eric Deconinick, Claude-Eric Bulabois, Edouard Forcade, Eleni Tholouli, Joost G K van der Hem, Peter van Balen, Jorinde Desiree Hoogenboom, Liesbeth C de Wreede, Florent Malard, Annalisa Ruggeri, Katharina Fleischhauer
来源：
BLOOD
摘要：
HLA-DP 允许错配可以根据其在核心和非核心子集上的免疫肽组差异来指定方向。与等位基因匹配对相比，非核心允许 GvH mM 显示复发风险显着降低（HR 0.77 [0.63-0.93]；p<0.001），且 NRM 不增加。版权所有 © 2024 美国血液学会。
HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and non-core subsets. Non-core permissive GvH mM show significantly reduced risks of relapse (HR 0.77 [0.63-0.93]; p<0.001) without increased NRM compared to allele-matched pairs.Copyright © 2024 American Society of Hematology.