放射性肺损伤的致病机制和最新治疗方法：叙述性回顾。
Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: a narrative review.
发表日期：2024 Aug 03
作者：
Sitong Chang, Jincai Lv, Xuanzhong Wang, Jing Su, Chenbin Bian, Zhuangzhuang Zheng, Huiyuan Yu, Jindian Bao, Ying Xin, Xin Jiang
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
摘要：
用电离辐射治疗胸部肿瘤可引起放射性肺损伤（RILI），包括放射性肺炎和放射性肺纤维化。预防 RILI 对于控制肿瘤生长和改善生活质量至关重要。然而，传统 RILI 治疗方法的严重副作用仍然是一个主要障碍，因此需要开发安全有效的新型治疗方案。本综述总结了 RILI 的分子机制，并探索了新的治疗方案，包括天然化合物、基因疗法、纳米材料和间充质干细胞。这些最近的实验方法显示出在临床实践中作为 RILI 有效预防和治疗选择的潜力。版权所有 © 2024。由 Elsevier B.V. 出版。
The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.Copyright © 2024. Published by Elsevier B.V.