pH响应肽、多肽及其超分子组装体在生物医学应用中的最新进展。
Recent Progress of pH-Responsive Peptides, Polypeptides, and Their Supramolecular Assemblies for Biomedical Applications.
发表日期：2024 Aug 06
作者：
Mingxuan Hou, Shiyong Liu
来源：
BIOMACROMOLECULES
摘要：
肽和多肽的侧链上具有多种活性官能团（包括羧酸、羟基、氨基和硫醇基团），可进行多种化学修饰。这种多功能性使它们在刺激响应系统中非常有价值。值得注意的是，pH 响应肽和多肽由于其响应 pH 变化的能力，在细胞病理学和肿瘤靶向中的应用具有重大前景。广泛的研究强调了低 pH 插入肽 (pHLIP)、肽-药物偶联物 (PDC) 和抗体-药物偶联物 (ADC) 在生物医学中的潜力。肽自组装体具有结构稳定性、易于调控、优异的生物相容性和生物降解性，在新型材料和生物医学应用的开发中具有巨大的潜力。我们还探讨了它们在药物输送、肿瘤靶向和组织工程中应用的具体例子，同时讨论了 pH 响应自组装肽基生物材料领域的未来挑战和潜在进展。
Peptides and polypeptides feature a variety of active functional groups on their side chains (including carboxylic acid, hydroxyl, amino, and thiol groups), enabling diverse chemical modifications. This versatility makes them highly valuable in stimuli-responsive systems. Notably, pH-responsive peptides and polypeptides, due to their ability to respond to pH changes, hold significant promise for applications in cellular pathology and tumor targeting. Extensive researches have highlighted the potentials of low pH insertion peptides (pHLIPs), peptide-drug conjugates (PDCs), and antibody-drug conjugates (ADCs) in biomedicine. Peptide self-assemblies, with their structural stability, ease of regulation, excellent biocompatibility, and biodegradability, offer immense potentials in the development of novel materials and biomedical applications. We also explore specific examples of their applications in drug delivery, tumor targeting, and tissue engineering, while discussing future challenges and potential advancements in the field of pH-responsive self-assembling peptide-based biomaterials.