非编码 RNA，尤其是 miRNA，在癌症发生和转移中发挥着关键作用，强调了它们对小分子抑制剂精确调节的敏感性。这篇综述探讨了用类药物小分子靶向致癌 miRNA 的创新策略，这种方法可以重塑癌症治疗格局。我们回顾了目前对 miRNA 在肿瘤发生中多方面作用的理解，强调了有潜力扩大癌症治疗选择的新兴治疗范例。由于 miRNA 小分子抑制剂的研究仍处于早期阶段，持续的研究工作以及新技术和化学物质的开发对于发挥这种创新癌症治疗方法的巨大潜力至关重要。版权所有 © 2024 Elsevier Inc. 所有权利预订的。

Noncoding RNAs, especially miRNAs, play a pivotal role in cancer initiation and metastasis, underscoring their susceptibility to precise modulation via small molecule inhibitors. This review examines the innovative strategy of targeting oncogenic miRNAs with small drug-like molecules, an approach that can reshape the cancer treatment landscape. We review the current understanding of the multifaceted roles of miRNAs in oncogenesis, highlighting emerging therapeutic paradigms that have the potential to expand cancer treatment options. As research on small molecule inhibitors of miRNA is still in its early stages, ongoing investigative efforts and the development of new technologies and chemical matter are essential to fulfill the significant potential of this innovative approach to cancer treatment.Copyright © 2024 Elsevier Inc. All rights reserved.