新认识的唾液腺肿瘤的更新:分子和免疫组织化学发现及临床重要性。
Update of newly-recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance.
发表日期:2024 Aug 07
作者:
Rachelle A Wolk, Nicole A Cipriani
来源:
HISTOPATHOLOGY
摘要:
随着分子检测的进步和免疫组织化学染色的常规使用,以前被分类为腺瘤或腺癌(未另有说明)的唾液腺肿瘤正在被重新分类为不同的诊断。新认识的良性实体包括:硬化性多囊腺瘤、角化囊肿、闰管增生和腺瘤、以及横纹管腺瘤。新认识的恶性唾液腺肿瘤包括:微分泌腺癌、硬化性小细胞腺癌和粘液腺癌。此外,还描述了粘液表皮样癌的罕见亚型,包括沃辛样癌和嗜酸细胞癌。对导管内癌的认识不断发展。正确区分这些病变与模仿者对于适当的患者护理和预测以及未来唾液疾病的概念化至关重要。© 2024 作者。组织病理学由约翰·威利出版
With the advancement of molecular testing and the routine use of immunohistochemical stains, salivary gland tumours previously categorized as adenoma or adenocarcinoma, not otherwise specified, are being reclassified with distinct diagnoses. Newly recognized benign entities include: sclerosing polycystic adenoma, keratocystoma, intercalated duct hyperplasia and adenoma, and striated duct adenoma. Newly recognized malignant salivary gland tumours include: microsecretory adenocarcinoma, sclerosing microcytic adenocarcinoma, and mucinous adenocarcinoma. Additionally, rare subtypes of mucoepidermoid carcinoma have been described, including Warthin-like and oncocytic. Understanding of intraductal carcinoma continues to evolve. Correctly distinguishing these lesions from mimickers can be crucial for appropriate patient care and prognostication, as well as future conceptualization of salivary disease.© 2024 The Author(s). Histopathology published by John Wiley & Sons Ltd.