揭开癌症生物学和治疗中 RNA 结合蛋白相分离的面纱。
Unveiling the veil of RNA binding protein phase separation in cancer biology and therapy.
发表日期：2024 Aug 05
作者：
Yunfan Lin, Jiarong Zheng, Zizhao Mai, Pei Lin, Ye Lu, Li Cui, Xinyuan Zhao
来源：
CANCER LETTERS
摘要：
肿瘤学中的 RNA 结合蛋白 (RBP) 相分离揭示了复杂的相互作用，对于理解肿瘤生物学和开发新的治疗策略至关重要。 RBP 的异常相分离显着影响基因调控、信号转导和代谢重编程，从而导致肿瘤发生和耐药性。我们的综述强调了 RBP 相分离在应激颗粒动力学、mRNA 稳定以及转录和翻译过程调节中的不可或缺的作用。此外，RBP 和非编码 RNA 之间的相互作用增加了一层复杂性，为它们在癌症进展中的协作作用提供了新的见解。 RBP 和相分离之间的复杂关系提出了重大挑战，但也为靶向治疗干预开辟了新的机会。增进我们对控制 RBP 相分离的分子机制和调控网络的理解可能会导致癌症治疗策略的突破。版权所有 © 2024 Elsevier B.V. 保留所有权利。
RNA-binding protein (RBP) phase separation in oncology reveals a complex interplay crucial for understanding tumor biology and developing novel therapeutic strategies. Aberrant phase separation of RBPs significantly influences gene regulation, signal transduction, and metabolic reprogramming, contributing to tumorigenesis and drug resistance. Our review highlights the integral roles of RBP phase separation in stress granule dynamics, mRNA stabilization, and the modulation of transcriptional and translational processes. Furthermore, interactions between RBPs and non-coding RNAs add a layer of complexity, providing new insights into their collaborative roles in cancer progression. The intricate relationship between RBPs and phase separation poses significant challenges but also opens up novel opportunities for targeted therapeutic interventions. Advancing our understanding of the molecular mechanisms and regulatory networks governing RBP phase separation could lead to breakthroughs in cancer treatment strategies.Copyright © 2024 Elsevier B.V. All rights reserved.