结直肠癌（CRC）是一种常见的恶性肿瘤，发病率和死亡率较高。尽管早期筛查和治疗方案有所增加，但结直肠癌患者的预后仍然较差，5 年生存率较低。因此，挖掘更多的治疗靶点、开发早期诊断和判断预后的手段是结直肠癌临床治疗的当务之急。铁死亡是一种最近发现的调节性细胞死亡（RCD）类型，其特征是铁依赖性脂质过氧化的积累，从而导致膜损伤和细胞死亡。最近的研究表明，铁死亡与肿瘤（包括结直肠癌）相关，并且可能参与结直肠癌的进展；然而，其潜在机制复杂且异质，尚未得到彻底总结。因此，本研究回顾了铁死亡在CRC进展中的作用，以针对铁死亡相关因素进行CRC治疗。还研究了铁死亡相关生物标志物和基因在结直肠癌早期诊断和预后中的意义。此外，还讨论了铁死亡研究在当前 CRC 治疗中的局限性以及未来的研究前景。© 作者。

Colorectal cancer (CRC) is a common malignant tumor associated with high morbidity and mortality. Despite an increase in early screening and treatment options, people with CRC still have a poor prognosis and a low 5-year survival rate. Therefore, mining more therapeutic targets and developing means of early diagnosis and determining prognosis are now imperative in the clinical treatment of CRC. Ferroptosis is a recently identified type of regulated cell death (RCD) characterized, which is identified by the accumulation of iron-dependent lipid peroxidation, thereby causing membrane damage and cell death. Recent studies have shown that ferroptosis is associated with tumors, including CRC, and can be involved in CRC progression; however, the underlying mechanisms are complex and heterogeneous and have not been thoroughly summarized. Therefore, this study reviewed the roles of ferroptosis in CRC progression to target ferroptosis-related factors for CRC treatment. The significance of ferroptosis-related biomarkers and genes in the early diagnosis and prognosis of CRC was also investigated. Furthermore, the limitations of ferroptosis studies in the current treatment of CRC, as well as future research perspectives, are discussed.© The author(s).