由创伤、感染和肿瘤切除引起的骨缺损相关疾病的高发极大地刺激了骨再生领域的研究。一般来说，骨愈合是一个漫长而复杂的过程，其中操纵介入支架的生物活性以支持长期骨再生对于治疗骨相关疾病具有重要意义。据报道，一些物理信号可以作为生长因子替代品，通过持续激活内源性信号通路来促进成骨。本综述重点关注通过远程驱动和按需激活预先结合物理信号（热、电和磁）的生物材料进行骨修复的最新进展。作为治疗骨缺损的替代方法，物理提示显示出许多优点，包括有效性、非侵入性和远程操作。首先，我们介绍不同物理线索对骨修复的影响和潜在的内部调节机制。随后，总结了在骨修复中介导各种物理信号的生物材料及其各自的特性。此外，还讨论了挑战，旨在为开发治疗骨缺损的智能生物材料和促进临床转化提供新的见解和建议。©作者。

The high incidence of bone defect-related diseases caused by trauma, infection, and tumor resection has greatly stimulated research in the field of bone regeneration. Generally, bone healing is a long and complicated process wherein manipulating the biological activity of interventional scaffolds to support long-term bone regeneration is significant for treating bone-related diseases. It has been reported that some physical cues can act as growth factor substitutes to promote osteogenesis through continuous activation of endogenous signaling pathways. This review focuses on the latest progress in bone repair by remote actuation and on-demand activation of biomaterials pre-incorporated with physical cues (heat, electricity, and magnetism). As an alternative method to treat bone defects, physical cues show many advantages, including effectiveness, noninvasiveness, and remote manipulation. First, we introduce the impact of different physical cues on bone repair and potential internal regulatory mechanisms. Subsequently, biomaterials that mediate various physical cues in bone repair and their respective characteristics are summarized. Additionally, challenges are discussed, aiming to provide new insights and suggestions for developing intelligent biomaterials to treat bone defects and promote clinical translation.© The author(s).