旨在阐明术前时间间隔对接受新辅助放化疗（nCRT）后再行食管切除术的食管癌患者的短期术后和病理结果的影响。术前时间间隔对接受多学科治疗的食管癌患者的影响尚不清楚。患者（使用 nCRT 加食管切除术治疗的 cT1-4aN0-3M0）被纳入荷兰国家 DUCA 数据库。使用多变量逻辑回归来确定不同时间间隔对短期术后和病理结果的影响：诊断到 nCRT 间隔（≤5、5-8 和 8-12 周）、nCRT 到手术间隔（5 -11、11-17 和 >17 周）和总术前间隔（≤16、16-25 和 >25 周）。2010 年至 2021 年期间，总共纳入了 5052 名患者。与诊断到nCRT间隔≤5周相比，间隔8-12周与总体并发症风险较高相关（P=0.049）。与 nCRT 至手术间隔 5-11 周相比，较长的间隔（11-17 周和 >17 周）与总体并发症（P 值=0.016；P 值<0.001）和吻合口瘘的风险较高相关。 （P 值=0.004；P 值=0.030），但间隔 >17 周与较低的 ypN 风险相关（P 值=0.021）。与间隔≤16周相比，较长的总术前间隔与30天死亡率和并发症的风险无关，但较长的总术前间隔（>25周）与较高的ypT分期相关（P值=0.010） pCR 率较低（P 值=0.013）。在接受 nCRT 和食管切除术的食管癌患者中，较长的术前时间间隔可能导致较高的发病率和疾病进展，其因果关系需要进一步确认。版权所有 © 2024 Wolters Kluwer Health，公司保留所有权利。

To clarify the impact of the preoperative time intervals on short-term postoperative and pathological outcomes in esophageal cancer patients who underwent neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy.The impact of preoperative intervals on esophageal cancer patients who received multimodality treatment remains unknown.Patients(cT1-4aN0-3M0) treated with nCRT plus esophagectomy were included using the Dutch national DUCA-database. Multivariate logistic regression was used to determine the effect of different time intervals upon short-term postoperative and pathological outcomes: diagnosis-to-nCRT intervals (≤5, 5-8 and 8-12 wk), nCRT-to-surgery intervals (5-11, 11-17 and >17 wk) and total preoperative intervals (≤16, 16-25 and >25 wk).Between 2010-2021, a total of 5052 patients were included. Compared to diagnosis-to-nCRT interval ≤5 weeks, the interval 8-12 weeks was associated with higher risk of overall complications (P=0.049). Compared to nCRT-to-surgery interval 5-11 weeks, the longer intervals (11-17 wk and >17 wk) were associated with higher risk of overall complications (P-value=0.016; P-value<0.001) and anastomotic leakage (P-value=0.004; P-value=0.030), but the interval >17 weeks was associated with lower risk of ypN+ (P-value=0.021). The longer total preoperative intervals were not associated with the risk of 30-day mortality and complications compared to the interval ≤16 weeks, but the longer total preoperative interval (>25 wk) was associated with higher ypT stage (P-value=0.010) and lower pCR rate (P-value=0.013).In patients with esophageal cancer undergoing nCRT and esophagectomy, prolonged preoperative time intervals may lead to higher morbidity and disease progression, and the causal relationship requires further confirmation.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.