尽管精准治疗和免疫疗法取得了重大进展，但肺癌仍然是全球癌症死亡的最常见原因。为了降低发病率并提高生存率，更深入地了解肺癌前病变和肿瘤发生的多步骤过程至关重要，以便在癌症发生之前进行及时有效的干预。总结现有信息，找出知识差距，制定研究问题，优先考虑潜在的研究主题，并提出未来研究肺部癌前进展的策略。一个由基础、转化和临床科学家组成的国际多学科团队审查了现有数据，以开发和完善与癌前肺部病变转化为晚期肺癌有关的研究问题。研究声明指出了知识上的重大差距，并提出了潜在的研究问题，旨在扩大我们对癌前肺部病变进展为肺癌的机制的理解，努力探索在新生阶段拦截肺癌的潜在创新方式。对肺部癌前进展的生物学机制的了解，以及筛查、检测和早期干预方面持续存在的挑战，凸显了优先考虑该领域研究的迫切需要。这种有针对性的研究对于制定有效的预防策略至关重要，最终可以降低肺癌发病率并改善患者的治疗结果。

Despite significant advances in precision treatments and immunotherapy, lung cancer is the most common cause of cancer death worldwide. To reduce incidence and improve survival rates, a deeper understanding of lung premalignancy and the multistep process of tumorigenesis is essential, allowing for timely and effective intervention before cancer development.To summarize existing information, identify knowledge gaps, formulate research questions, prioritize potential research topics, and propose strategies for future investigations into the premalignant progression in the lung.An international multidisciplinary team of basic, translational, and clinical scientists reviewed available data to develop and refine research questions pertaining to the transformation of premalignant lung lesions to advanced lung cancer.This research statement identifies significant gaps in knowledge and proposes potential research questions aimed at expanding our understanding of the mechanisms underlying the progression of premalignant lung lesions to lung cancer in an effort to explore potential innovative modalities to intercept lung cancer at its nascent stages.The identified gaps in knowledge about the biological mechanisms of premalignant progression in the lung, along with ongoing challenges in screening, detection, and early intervention, highlight the critical need to prioritize research in this domain. Such focused investigations are essential to devise effective preventive strategies that may ultimately decrease lung cancer incidence and improve patient outcomes.