本研究旨在利用磁共振成像识别潜在的解剖变异触发因素，以调整宫颈癌患者的计划，以确保在外照射放射治疗过程中满足剂量要求。将治疗前和治疗期间采集的磁共振图像 (MRI) 严格配准到 11 个回顾性宫颈癌数据集的治疗前计算机断层扫描 (CT) 图像。在 MRI 上描绘了目标体积 (TV) 和危险器官 (OAR)，并将其传播到 CT 上。治疗计划是根据治疗前轮廓生成的，并应用于治疗中期轮廓。评估每个时间点之间的解剖学和剂量学变化。解剖学变化包括质心位置和体积大小的变化。剂量变化包括 OAR 的 V30Gy 和 V40Gy，以及 TV 的 V95%、V100%、D95% 和 D98%。评估与剂量测定和解剖变化的相关性以确定潜在的重新计划触发因素。肠道体积和上下方向位置的变化以及高危CTV前后位置分别与肠道和目标剂量的变化高度相关。因此，肠道变化和高危 CTV 可以作为潜在的重新计划触发因素。© 2024。作者。

This study aimed to identify potential anatomical variation triggers using magnetic resonance imaging for plan adaption of cervical cancer patients to ensure dose requirements were met over an external beam radiotherapy course. Magnetic resonance images (MRIs) acquired before and during treatment were rigidly registered to a pre-treatment computerised tomography (CT) image for 11 retrospective cervix cancer datasets. Target volumes (TVs) and organs at risk (OARs) were delineated on both MRIs and propagated onto the CT. Treatment plans were generated based on the pre-treatment contours and applied to the mid-treatment contours. Anatomical and dosimetric changes between each timepoint were assessed. The anatomical changes included the change in centroid position and volume size. Dosimetric changes included the V30Gy and V40Gy for the OARs, and V95%, V100%, D95% and D98% for the TVs. Correlation with dosimetric and anatomical changes were assessed to determine potential replan triggers. Changes in the bowel volume and position in the superior-inferior direction, and the high-risk CTV anterior posterior position were highly correlated with a change in dose to the bowel and target, respectively. Hence changes in bowel and high-risk CTV could be used as a potential replan triggers.© 2024. The Author(s).