聚合 N-亚硝胺基一氧化氮 (NO) 供体及其治疗应用的最新进展。
Recent Advancements in Polymeric N-Nitrosamine-Based Nitric Oxide (NO) Donors and their Therapeutic Applications.
发表日期：2024 Aug 08
作者：
Anushree Mondal, Soumya Paul, Priyadarsi De
来源：
BIOMACROMOLECULES
摘要：
一氧化氮 (NO) 是一种气体递质，以其在血管舒张、心脏舒张和血管生成方面的广泛作用而闻名。这种双原子自由基在降低血小板聚集和血栓形成的风险方面也发挥着关键作用。此外，NO 在癌症治疗以及较高浓度的抗菌和抗生物膜活性方面表现出巨大的潜力。为了利用其生物医学活动，已经开发了许多NO供体。其中，N-亚硝胺正在成为一个值得注意的类别，能够在适当的光照射下释放 NO，并具有广泛的治疗应用。这篇综述讨论了聚合 N-亚硝胺的设计、合成和生物应用，强调了它们在稳定性、NO 有效负载和目标特异性递送方面相对于小分子 NO 供体的优势。此外，还探索了各种小分子 N-亚硝胺，以全面概述这一新兴领域。我们预计本次审查将有助于开发具有改进的物理化学性质的下一代聚合 N-亚硝胺。
Nitric oxide (NO), a gasotransmitter, is known for its wide range of effects in vasodilation, cardiac relaxation, and angiogenesis. This diatomic free radical also plays a pivotal role in reducing the risk of platelet aggregation and thrombosis. Furthermore, NO demonstrates promising potential in cancer therapy as well as in antibacterial and antibiofilm activities at higher concentrations. To leverage their biomedical activities, numerous NO donors have been developed. Among these, N-nitrosamines are emerging as a notable class, capable of releasing NO under suitable photoirradiation and finding a broad range of therapeutic applications. This review discusses the design, synthesis, and biological applications of polymeric N-nitrosamines, highlighting their advantages over small molecular NO donors in terms of stability, NO payload, and target-specific delivery. Additionally, various small-molecule N-nitrosamines are explored to provide a comprehensive overview of this burgeoning field. We anticipate that this review will aid in developing next-generation polymeric N-nitrosamines with improved physicochemical properties.