与肠道微生物特征相关的经验饮食模式与结直肠癌风险相关。
An Empirical Dietary Pattern Associated with the Gut Microbial Features in Relation to Colorectal Cancer Risk.
发表日期：2024 Aug 06
作者：
Kai Wang, Chun-Han Lo, Raaj S Mehta, Long H Nguyen, Yiqing Wang, Wenjie Ma, Tomotaka Ugai, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Kosuke Mima, Kota Arima, Kazuo Okadome, Marios Giannakis, Cynthia L Sears, Jeffrey A Meyerhardt, Kimmie Ng, Nicola Segata, Jacques Izard, Eric B Rimm, Wendy S Garrett, Curtis Huttenhower, Edward L Giovannucci, Andrew T Chan, Shuji Ogino, Mingyang Song
来源：
GASTROENTEROLOGY
摘要：
饮食通过肠道微生物组影响结直肠癌 (CRC) 风险的流行病学证据仍然有限。利用 307 名男性和 212 名女性的粪便宏基因组和饮食数据，我们描述并验证了与 CRC 相关肠道微生物相关的性别特异性饮食模式签名（CRC 微生物膳食评分 [CMDS]）。我们根据卫生专业人员随访研究（1986-2018 年）、护士的临床实践中的 Cox 比例风险回归，根据肿瘤组织中的具核梭杆菌、pks 大肠杆菌和产肠毒素脆弱拟杆菌 (ETBF) 状态，评估了 CMDS 与 CRC 风险的关联。健康研究 (NHS)（1984-2020）和 NHS II（1991-2019）。CMDS 的特点是高度工业加工食品和低未加工富含纤维的食物摄入量。在 6,467,378 人年的随访中，我们记录了 259,200 名参与者中的 3,854 起 CRC 事件。 CMDS 与较高的 CRC 风险相关（Ptrend<0.001），多变量风险比（HRQ5vs.Q1）为 1.25（95%CI，1.13-1.39）。在调整先前建立的饮食模式（例如西方和谨慎饮食）后，这种关联仍然存在。值得注意的是，肿瘤性具核梭菌阳性（HRQ5vs.Q1，2.51；95%CI，1.68-3.75；Ptrend<0.001）（Pheterogeneity=0.03，阳性与阴性）、pks 大肠杆菌阳性（ HRQ5vs.Q1，1.68；95%CI，0.84-3.38；Ptrend=0.005）（异质性=0.01，阳性与阴性），以及 ETBF 阳性 CRC（HRQ5vs.Q1，2.06；95%CI，1.10-3.88；Ptrend） =0.016)（异质性=0.06，阳性与阴性），与阴性对应物相比。CMDS 与 CRC 风险增加相关，特别是对于组织中可检测到具核梭菌、pks 大肠杆菌和 ETBF 的肿瘤。我们的研究结果支持肠道微生物组在饮食对 CRC 影响中的潜在作用。版权所有 © 2024 AGA Institute。由爱思唯尔公司出版。保留所有权利。
Epidemiologic evidence for dietary influence on colorectal cancer (CRC) risk through the gut microbiome remains limited.Leveraging 307 men and 212 women with stool metagenomes and dietary data, we characterized and validated a sex-specific dietary pattern associated with the CRC-related gut microbial signature (CRC Microbial Dietary Score [CMDS]). We evaluated the associations of CMDS with CRC risk according to Fusobacterium nucleatum, pks+Escherichia coli, and enterotoxigenic Bacteroides fragilis (ETBF) status in tumor tissue using Cox proportional hazards regression in the Health Professionals Follow-up Study (1986-2018), Nurses' Health Study (NHS) (1984-2020), and NHS II (1991-2019).The CMDS was characterized by high industrially processed foods and low unprocessed fiber-rich foods intakes. In 259,200 participants, we documented 3,854 incident CRC cases over 6,467,378 person-years of follow-up. CMDS was associated with a higher risk of CRC (Ptrend<0.001), with a multivariable hazard ratio (HRQ5vs.Q1) of 1.25 (95%CI, 1.13-1.39). The association remained after adjusting for previously established dietary patterns, e.g., the Western and prudent diets. Notably, the association was stronger for tumoral F. nucleatum-positive (HRQ5vs.Q1, 2.51; 95%CI, 1.68-3.75; Ptrend<0.001) (Pheterogeneity=0.03, positivity vs. negativity), pks+E. coli-positive (HRQ5vs.Q1, 1.68; 95%CI, 0.84-3.38; Ptrend=0.005) (Pheterogeneity=0.01, positivity vs. negativity), and ETBF-positive CRC (HRQ5vs.Q1, 2.06; 95%CI, 1.10-3.88; Ptrend=0.016) (Pheterogeneity=0.06, positivity vs. negativity), compared with their negative counterparts.CMDS was associated with increased CRC risk, especially for tumors with detectable F. nucleatum, pks+E. coli, and ETBF in tissue. Our findings support a potential role of the gut microbiome underlying the dietary effects on CRC.Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.