研究动态
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糖和含糖饮料与儿童癌症成年幸存者过早衰老的关系。

Sugar and sugar-sweetened beverages in relation to premature aging in adult survivors of childhood cancer.

发表日期:2024 Aug 08
作者: Tuo Lan, Mei Wang, AnnaLynn M Williams, Matthew J Ehrhardt, Shu Jiang, I-Chan Huang, Jennifer Q Lanctot, Kevin R Krull, Gregory T Armstrong, Melissa M Hudson, Graham A Colditz, Leslie L Robison, Kirsten K Ness, Yikyung Park
来源: BRITISH JOURNAL OF CANCER

摘要:

过早衰老是儿童期癌症成年幸存者的一个重大问题,因为他们比没有儿童期癌症病史的同龄人更年轻地患上衰老相关疾病。尽管饮食等可改变的生活方式因素被认为会影响衰老过程,但支持证据很少。我们对圣裘德地区 3322 名儿童癌症成年幸存者进行了检查,了解糖和含糖饮料的摄入是否与过早衰老有关。终生队列。使用赤字累积指数(DAI)评估过早衰老,该指数是每个幸存者患有与年龄相关的慢性健康状况的数量在总共 44 种疾病中的比率。使用针对混杂因素进行调整的多项逻辑回归来估计比值比 (OR) 和 95% 置信区间 (CI)。有 46% 的儿童癌症幸存者每天食用一次或多次 SSB。大量摄入糖,特别是在制备或加工过程中添加到食品中的糖,以及习惯性饮用含糖饮料,与过早衰老的风险增加有关。我们的研究结果支持需要制定减少糖和含糖饮料消费的策略生活方式干预,以促进儿童癌症成年幸存者的健康老龄化。© 2024。作者,获得施普林格自然有限公司的独家许可。
Premature aging is a significant concern in adult survivors of childhood cancer as they develop aging-related conditions at a younger age than their peers with no history of childhood cancer. Although modifiable lifestyle factors, such as diet, are postulated to affect aging process, supporting evidence is sparse.We examined if the consumption of sugar and sugar-sweetened beverages was related to premature aging in 3322 adult survivors of childhood cancer in the St. Jude Lifetime Cohort. Premature aging was assessed using the Deficit Accumulation Index (DAI) that was a ratio of the number of age-related chronic health conditions each survivor had out of 44 conditions total. Multinomial logistic regressions adjusting for confounders were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).There were 46% of childhood cancer survivors consumed SSBs once or more times per day. High intake of sugar, especially sugars added to foods during preparation or processing, and habitual consumption of sugar-sweetened beverage were associated with an increased risk of premature aging.Our findings support a need to include strategies to reduce sugar and sugar-sweetened beverages consumption in lifestyle interventions to promote healthy aging in adult survivors of childhood cancer.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.