关于胰腺腺癌 (PA) 环境风险因素（包括农药暴露）的了解仍然有限。有机氯 (OC) 在脂肪组织中积聚，有助于反映长期暴露情况。PA 患者的年龄和体重指数 (BMI) 与接受良性疾病手术的患者的年龄和 BMI 相匹配 (1:1)。针对性分析筛选了脂肪组织和尿液样本中的 345 种农药和代谢物，其中包括 29 种 OC。主要目的是研究内脏脂肪或尿液中的有机氯浓度与 PA 之间的关联。考虑到多重测试，进行了调整后的条件逻辑回归。反式九草胺（比值比 [OR] = 1.325，95% 置信区间 [CI] [1.108-1.586]），顺式九草胺（OR = 15.433，95% CI [ 2.733-87.136]）、脂肪中的 Mirex（OR = 2.853，95% CI [1.213-6.713]）和 4,4 DDE（OR = 1.019，95% CI [1.005-1.034]）以及更多的阳性样本（ OR = 1.758 95% CI [1.11-2.997]）与较高的 PA 几率显着相关。相比之下，正如所期待的那样，尿液样本并未对所有测试的农药产生任何统计上显着的关联。一些 OC 与较高的 PA 几率相关。需要研究胰腺攻击的潜在机制以完善这些发现。Clinicaltrials.gov NCT04429490.© 2024 作者。 《联合欧洲胃肠病学杂志》由 Wiley periodicals LLC 代表联合欧洲胃肠病学出版。

Knowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long-term exposure.Age and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.Trans-nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108-1.586]), cis-nonachlor (OR = 15.433, 95% CI [2.733-87.136]), Mirex (OR = 2.853, 95% CI [1.213-6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005-1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11-2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.Some OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.Clinicaltrials.gov NCT04429490.© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.