侵入性纤维状腺大小和格里森评分百分比的预后意义7前列腺腺癌
Prognostic significance of invasive cribriform gland size and percentage in Gleason score 7 prostate adenocarcinoma
影响因子:1.90000
分区:医学4区 / 病理学3区
发表日期:2024 Aug 09
作者:
Emel Tekin, Nazlı Sena Şeker, Ata Özen, Mustafa Fuat Açıkalın, Cavit Can, Ertuğrul Çolak
摘要
曲线腺与前列腺腺癌中的较差结果有关。我们的目的是评估格里森评分中纤维状腺比例百分比的预后作用以及最大的浸润性纤维状腺体的大小7前列腺腺癌。对177级和3级的indenercin consirencion and Insectial consitial contocial and Insectial conterial contirencion and Insectial contirencion contirencion and consircin consior conseiber-rcii conseiber-rcii rcii cobin concin consipial contircin contircin。在纤维状腺体百分比大于10％（p <.001）的情况下，并且在最大的浸润性纤维状腺大小大于0.5 mm（p <.001）的情况下，生存率显着降低。平均最大的绿色腺体大小和百分比具有统计学意义，与更先进的PT状态，淋巴结转移，生化复发性以及较高的术前前列腺特异性特异性抗原值相关。我们建议，在2年级和3年级的3例中，可能需要采用更具侵略性的临床方法，其肌肉腺体大于0.5 mm，并且绿色腺体百分比大于10％，尤其是在前列腺针头活检标本中。版权所有。有关商业重复使用，请联系reprints@oup.com，以获取转载和翻译权以进行转载。所有其他权限都可以通过我们的restrimlink服务通过我们网站上文章页面上的“权限链接”获得 - 有关更多信息，请联系journals.permissions.permissions@oup.com。
Abstract
Cribriform glands are linked to poorer outcomes in prostate adenocarcinoma. We aimed to assess the prognostic role of the percentage of cribriform glands and the size of the largest invasive cribriform gland in Gleason score 7 prostate adenocarcinomas.The presence, percentage, and size of the invasive cribriform glands were investigated and their association with prognostic factors were assessed in 177 Grade Groups 2 and 3 prostate adenocarcinomas.Biochemical recurrence-free survival was statistically significantly lower in cases with a cribriform gland percentage greater than 10% (P < .001) and in cases where the largest invasive cribriform gland size was greater than 0.5 mm (P < .001). Mean largest cribriform gland size and percentage were statistically significant associated with more advanced pT status, lymph node metastasis, biochemical recurrence, and higher preoperative prostate-specific antigen values.Our findings suggest that the presence of a cribriform pattern, increases in the percentage of such patterns, and increases in the size of the largest cribriform gland within a given tumor are associated with poor prognosis. We suggest that a more aggressive clinical approach may be needed in Grade Group 2 and 3 cases with invasive cribriform glands larger than 0.5 mm and a cribriform gland percentage greater than 10%, especially in prostate needle biopsy specimens.© The Author(s) 2024. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.