癌症、炎症性疾病、神经系统疾病等多种致命疾病的发生和病程与HDAC8密切相关。因此，新型 HDAC8 抑制剂代表了可能有助于治疗这些疾病的有效治疗可能性。迄今为止，还没有任何此类特定的 HDAC8 抑制剂可供出售。本次审查旨在审查过去十年内已获得专利的最新 HDAC8 抑制剂。本次审查重点关注过去十年内发布的 HDAC8 抑制剂相关专利及其治疗应用，可通过 Patentscope 和 Google Patents 访问过去十年中已经提交了一些与 HDAC8 抑制剂相关的专利，这些专利更具选择性和特异性，旨在治疗多种医学疾病。这可能会导致针对 HDAC8 的新型治疗方法的开发。采用理论框架和实验程序可以揭示具有增强的药代动力学特征的新型 HDAC8 抑制剂的创建。有必要全面了解 HDAC8 抑制剂在癌症中的作用，包括 HDAC8 在其他疾病中的机制。

The processes and course of several fatal illnesses, such as cancer, inflammatory diseases, and neurological disorders, are closely correlated with HDAC8. Therefore, novel HDAC8 inhibitors represent effective therapeutic possibilities that may help treat these conditions. To yet, there aren't any such particular HDAC8 inhibitors available for sale. This review was conducted to examine recent HDAC8 inhibitors that have been patented over the last ten years.This review focuses on HDAC8 inhibitor-related patents and their therapeutic applications that have been published within the last ten years and are accessible through the Patentscope and Google Patents databases.A handful of HDAC8 inhibitor-related patents have been submitted over the previous ten years, more selective, and specific HDAC8 inhibitors that are intended to treat a variety of medical diseases. This could lead to the development of novel treatment approaches that target HDAC8. Employing theoretical frameworks and experimental procedures can reveal the creation of new HDAC8 inhibitors with enhanced pharmacokinetic characteristics. A thorough understanding of the role that HDAC8 inhibitors play in cancer including the mechanisms behind HDAC8 in other disorders is necessary.