研究动态
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术中手术导航作为鼻窦和颅面肿瘤手术的精准医疗工具。

Intraoperative surgical navigation as a precision medicine tool in sinonasal and craniofacial oncologic surgery.

发表日期:2024 Aug 08
作者: Piergiorgio Gaudioso, Giacomo Contro, Stefano Taboni, Paola Costantino, Francesca Visconti, Mosè Sozzi, Daniele Borsetto, Rishi Sharma, John De Almeida, Benjamin Verillaud, Alessandro Vinciguerra, Florent Carsuzaa, Juliette Thariat, Alperen Vural, Alberto Schreiber, Davide Mattavelli, Vittorio Rampinelli, Paolo Battaglia, Mario Turri-Zanoni, Apostolos Karligkiotis, Andrea Pistochini, Alberto Daniele Arosio, Alessia Lambertoni, Deepa Nair, Iacopo Dallan, Pierluigi Bonomo, Marinella Molteni, Badr El Khouzai, Fabio Busato, Elisabetta Zanoletti, Marco Krengli, Ester Orlandi, Piero Nicolai, Marco Ferrari
来源: ORAL ONCOLOGY

摘要:

最近的证据支持手术导航(SN)在改善鼻窦和颅面肿瘤手术结果方面的功效。本研究旨在证明 SN 作为整合手术、放射学和病理信息的工具的实用性。此外,还设计了一种用于记录和绘制活检样本的系统,以促进空间信息的共享。SN 在 10 例鼻腔/颅面肿瘤手术中用于活检绘制。采访了 25 名具有前颅底肿瘤学经验的评估者,根据地形描述和手术视频剪辑,在术前成像中识别出 15 个解剖结构。使用 SN 映射坐标作为参考,分析了评估者对解剖结构定位的差异(该差异定义为空间误差)。分析显示平均空间误差为 9.0 毫米(95% 置信区间:8.3- 9.6 毫米),外科医生和放射肿瘤科医生之间存在显着差异(分别为 7.9 毫米与 12.5 毫米,p < 0.0001)。所提出的 SN 映射坐标传输模型可以作为多学科讨论和放射治疗计划咨询的工具。当前评估疾病扩展和边缘状态的标准方法与接近 1 厘米的空间误差相关,这可能会影响治疗精度和结果。该研究强调了 SN 在提高空间精度和信息共享方面的潜力。需要进一步研究将该方法纳入多学科工作流程并衡量其对结果的影响。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。
Recent evidence supports the efficacy of surgical navigation (SN) in improving outcomes of sinonasal and craniofacial oncologic surgery. This study aims to demonstrate the utility of SN as a tool for integrating surgical, radiologic, and pathologic information. Additionally, a system for recording and mapping biopsy samples has been devised to facilitate sharing of spatial information.SN was utilized for biopsy mapping in 10 sinonasal/craniofacial oncologic procedures. Twenty-five raters with experience in anterior skull base oncology were interviewed to identify 15 anatomical structures in preoperative imaging, relying on topographical descriptions and surgical video clips. The difference in the localization of anatomical structures by raters was analyzed, using the SN-mapped coordinates as a reference (this difference was defined as spatial error).The analysis revealed an average spatial error of 9.0 mm (95 % confidence interval: 8.3-9.6 mm), with significant differences between surgeons and radiation oncologists (7.9 mm vs 12.5 mm, respectively, p < 0.0001). The proposed model for transferring SN-mapped coordinates can serve as a tool for consultation in multidisciplinary discussions and radiotherapy planning.The current standard method to evaluate disease extension and margin status is associated with a spatial error approaching 1 cm, which could affect treatment precision and outcomes. The study emphasizes the potential of SN in increasing spatial precision and information sharing. Further research is needed to incorporate this method into a multidisciplinary workflow and measure its impact on outcomes.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.