了解脊髓星形细胞瘤：分子机制、治疗和综合管理。
Understanding Spinal Cord Astrocytoma: Molecular Mechanism, Therapy, and Comprehensive Management.
发表日期：2024 Aug 07
作者：
Bo Pang, Songyuan An, Yun Liu, Tao Jiang, Wenqing Jia, Ruichao Chai, Yongzhi Wang
来源：
CANCER LETTERS
摘要：
脊髓星形细胞瘤是一种罕见且使人高度衰弱的肿瘤，但与大脑中的相应肿瘤相比，我们对其临床特征、分子特征和发病机制的了解仍然有限。目前脊髓星形细胞瘤的诊断和治疗方法主要基于脑星形细胞瘤的既定指南。然而，最近的研究揭示了脊髓星形细胞瘤与相应脑部星形细胞瘤的独特临床和病理特征。这些发现强调了直接将针对脑星形细胞瘤制定的临床指南应用于脊髓星形细胞瘤的不足。在这篇综述中，我们提供了了解脊髓星形细胞瘤方面进展的最新概述。我们还讨论了该领域的挑战和未来的研究前景，旨在提高这些肿瘤诊断和治疗的精度。具体来说，我们强调了加强对脊髓星形细胞瘤的分子异质性、免疫特征和临床试验的理解的重要性。版权所有 © 2024。由 Elsevier B.V. 出版。
Spinal cord astrocytoma is a rare and highly debilitating tumor, yet our knowledge of its clinical characteristics, molecular features, and pathogenesis remains limited compared to that of its counterparts in the brain. Current diagnostic and therapeutic approaches for spinal cord astrocytomas are primarily based on established guidelines for brain astrocytomas. However, recent studies have revealed unique clinical and pathological attributes that distinguish spinal cord astrocytomas from their corresponding brain counterparts. These findings underscore the inadequacy of directly applying the clinical guidelines developed for brain astrocytomas to spinal astrocytomas. In this review, we provided an up-to-date overview of the advancements in understanding spinal cord astrocytomas. We also discussed the challenges and future research prospects in this field with the aim of improving the precision of diagnosis and therapy for these tumors. Specifically, we emphasized the importance of enhancing our understanding of the molecular heterogeneity, immune characteristics, and clinical trials of spinal cord astrocytomas.Copyright © 2024. Published by Elsevier B.V.