结直肠癌（CRC）是最常见的恶性肿瘤之一，死亡率很高，尤其是在晚期发现时。在大多数情况下，尽管已经确定了一些环境和内在风险因素，但结直肠癌的基本病因仍不清楚。大量研究，特别是过去十年的研究表明，表观遗传变量与此类癌症有关。 CRC 的发生、进展和转移受到长非编码 RNA (lncRNA) 的影响，它们在表观遗传途径中发挥着重要作用。 LncRNA 与 CRC 的多种病理过程有关，例如肝转移、上皮间质转化 (EMT)、炎症和化疗/放疗耐药。最近确定CRC细胞和组织表现出数十种致癌和肿瘤抑制lncRNA的失调。结直肠癌患者的血清样本表现出其中几种转录物的表达失调，这为检测此类癌症提供了一种非侵入性方法。在这篇综述中，我们概述了解除管制的 lncRNA 的典型范例，它们在 CRC 发生和进展的潜在分子机制中发挥着重要作用。我们全面讨论了 lncRNA 作为 CRC 预后和治疗创新靶点的作用。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Colorectal cancer (CRC) being one of the most common malignancies, has a significant death rate, especially when detected at an advanced stage. In most cases, the fundamental aetiology of CRC remains unclear despite the identification of several environmental and intrinsic risk factors. Numerous investigations, particularly in the last ten years, have indicated the involvement of epigenetic variables in this type of cancer. The development, progression, and metastasis of CRC are influenced by long non-coding RNAs (lncRNAs), which are significant players in the epigenetic pathways. LncRNAs are implicated in diverse pathological processes in CRC, such as liver metastasis, epithelial to mesenchymal transition (EMT), inflammation, and chemo-/radioresistance. It has recently been determined that CRC cells and tissues exhibit dysregulation of tens of oncogenic and tumor suppressor lncRNAs. Serum samples from CRC patients exhibit dysregulated expressions of several of these transcripts, offering a non-invasive method of detecting this kind of cancer. In this review, we outlined the typical paradigms of the deregulated lncRNA which exert significant role in the underlying molecular mechanisms of CRC initiation and progression. We comprehensively discuss the role of lncRNAs as innovative targets for CRC prognosis and treatment.Copyright © 2024 Elsevier Inc. All rights reserved.