免疫检查点抑制剂（ICI）疗法是一种新型抗肿瘤策略，通过激活免疫系统、抑制肿瘤免疫逃逸来特异性消灭肿瘤。然而，ICI 治疗可能会导致显着的负面结果，称为免疫相关不良事件 (irAE)。 ICI 诱导的关节炎，也称为 ICI 关节炎，是 irAE 的主要形式。本综述的目的是强调 T 细胞在 ICI 关节炎进展中的关键功能。在不同信号分子的影响下，T细胞在关节滑膜内大量聚集，释放炎症物质和酶，损害健康组织，最终引起ICI关节炎。此外，考虑到T细胞在引发ICI关节炎中的功能，本综述提出了几种预防ICI关节炎的治疗方法，包括抑制关节滑膜囊T细胞的过度刺激、提高ICI药物的精准度以及将ICI药物专门针对肿瘤组织而不是关节。总的来说，T 淋巴细胞在 ICI 关节炎的发病过程中发挥着至关重要的作用，这为通过特异性靶向受影响关节内的 T 细胞来治疗 ICI 关节炎提供了充满希望的前景。

Immune checkpoint inhibitor (ICI) therapy, a novel anti-tumor strategy, can specifically eliminate tumors by activating the immune system and inhibiting tumor immune escape. However, ICI therapy can lead to notable negative outcomes known as immune-related adverse events (irAEs). ICI-induced arthritis, also known as ICI arthritis, stands as the prevailing form of irAEs. The purpose of this review is to highlight the crucial functions of T cells in the progression of ICI arthritis. Under the influence of different signaling molecules, T cells could gather in large numbers within the synovial membrane of joints, releasing inflammatory substances and enzymes that harm healthy tissues, ultimately causing ICI arthritis. Moreover, considering the functions of T cells in triggering ICI arthritis, this review suggests several treatments to prevent ICI arthritis, including inhibiting the overstimulation of T cells at the synovial sac of joints, enhancing the precision of ICI medications, and directing ICI drugs specifically towards tumor tissues instead of joints. Collectively, T lymphocytes play a vital role in the onset of ICI arthritis, offering a hopeful perspective on treating ICI arthritis through the specific targeting of T cells within the affected joints.