脂肪干细胞及其与癌细胞和线粒体库的相互作用：一个新的有希望的目标。
Adipose Stem Cells and Their Interplay with Cancer Cells and Mitochondrial Reservoir: A New Promising Target.
发表日期：2024 Aug 05
作者：
Ayesha Rehman, Martina Marigliano, Martina Torsiello, Marcella La Noce, Gianpaolo Papaccio, Virginia Tirino, Vitale Del Vecchio, Federica Papaccio
来源：
Cancers
摘要：
脂肪干细胞（ASC）显着影响肿瘤微环境（TME）内的肿瘤进展。本综述探讨了 ASC 的促肿瘤作用，重点关注旁分泌信号传导、直接细胞间相互作用和免疫调节。 ASC 介导的通过隧道纳米管 (TNT) 和间隙连接 (GJ) 的线粒体转移在增强癌细胞存活和代谢方面发挥着重要作用。线粒体功能失调的癌细胞从 ASC 获取线粒体以满足其代谢需求并在 TME 中茁壮成长。靶向线粒体转移、调节 ASC 功能和影响代谢途径是潜在的治疗策略。然而，必须解决 TME 复杂性、特异性、安全问题和耐药机制等挑战。破坏 ASC-癌细胞-线粒体轴为癌症治疗提供了一种有前途的方法。
Adipose-derived stem cells (ASCs) significantly influence tumor progression within the tumor microenvironment (TME). This review examines the pro-tumorigenic roles of ASCs, focusing on paracrine signaling, direct cell-cell interactions, and immunomodulation. ASC-mediated mitochondrial transfer through tunneling nanotubes (TNTs) and gap junctions (GJs) plays a significant role in enhancing cancer cell survival and metabolism. Cancer cells with dysfunctional mitochondria acquire mitochondria from ASCs to meet their metabolic needs and thrive in the TME. Targeting mitochondrial transfer, modulating ASC function, and influencing metabolic pathways are potential therapeutic strategies. However, challenges like TME complexity, specificity, safety concerns, and resistance mechanisms must be addressed. Disrupting the ASC-cancer cell-mitochondria axis offers a promising approach to cancer therapy.