作者的目的是评估脑膜瘤的生长速度和模式，并将肿瘤生长动力学与之前报告的两项放射学风险分层和 CNS WHO 分级（第 5 版，2021 年）联系起来。作者进行了一系列体积分析对 2003 年至 2015 年间在该机构通过放射学诊断的脑膜瘤进行了分析。主要终点是直径扩张速度 (VDE)，它代表平均肿瘤直径随时间的线性回归的斜率。对于二次分析，他们通过将时间-体积曲线拟合到线性和指数函数，将生长模式分类为线性或指数。比较了基于 T2 加权等/高信号和无钙化的三种放射学风险类别：低风险（T2 加权低信号）、中风险（T2 加权等/高信号伴钙化）和高风险（T2 加权等/高信号）对于 240 个脑膜瘤的整个队列，中位 (IQR) VDE 为 0.33 (0.00-0.71) mm/年。 VDE 的分布在放射风险类别之间存在显着差异（0.49 vs 0.35 vs 0.05 mm/年，p < 0.001）。与低风险肿瘤相比，高风险和中风险肿瘤更容易呈指数增长（43.8% vs 37.0% vs 8.3%，p = 0.067）。作者发现，在他们的队列中，生长速度与 CNS WHO 等级没有相关性（CNS WHO 1 级为 1.30 毫米/年，CNS WHO 2 级为 4.01 毫米/年，p = 0.185）。使用两个参数 T2 进行放射学风险评估-加权信号iso/高信号和钙化的缺失-允许估计未经治疗的颅内脑膜瘤的生长速度和特征。只有高风险肿瘤才表现出快速生长的潜力。然而，肿瘤的快速生长并不表明 CNS WHO 等级本身较高。

The authors' aim was to assess the velocity and pattern of growth of meningiomas and to correlate the kinetics of tumor growth with their previously reported two-item radiological risk stratification and CNS WHO grade (5th edition, 2021).The authors performed a serial volumetric analysis of meningiomas diagnosed radiologically at their institution between 2003 and 2015. The primary endpoint was velocity of diametric expansion (VDE), which represents the slope of the linear regression of the mean tumor diameter against time. For the secondary analysis, they categorized the growth patterns as linear or exponential by fitting time-volume curves to a linear and exponential function. Three radiological risk categories based on T2-weighted iso/hyperintensity and absence of calcifications were compared: low risk (T2-weighted hypointense), intermediate-risk (T2-weighted iso/hyperintense with calcifications), and high-risk (T2-weighted iso/hyperintense without calcifications) tumors.For the entire cohort of 240 meningiomas, the median (IQR) VDE was 0.33 (0.00-0.71) mm/year. Distribution of VDE differed significantly among radiological risk categories (0.49 vs 0.35 vs 0.05 mm/year, p < 0.001). High-risk and intermediate-risk tumors more frequently tended to grow exponentially compared to low-risk tumors (43.8% vs 37.0% vs 8.3%, p = 0.067). The authors found no correlation of growth velocity with CNS WHO grade in their cohort (1.30 mm/year for CNS WHO grade 1 vs 4.01 mm/year for CNS WHO grade 2, p = 0.185).A radiological risk assessment using two parameters-T2-weighted signal iso/hyperintensity and absence of calcifications-allows estimation of growth velocity and characteristics of untreated intracranial meningiomas. Only high-risk tumors exhibit the potential for rapid growth. However, rapid tumor growth does not indicate a higher CNS WHO grade per se.