乳腺癌是女性中最常见的癌症。乳腺癌的手术治疗已逐渐从根治性乳房切除术过渡到保乳手术。在这项荟萃分析中，我们的目的是比较肿瘤整形保乳手术 (OS) 与传统保乳手术 (BCS) 的疗效和安全性。我们检索了 Medline、Web of Science、Embase、Cochrane 数据库、临床试验。 gov、CNKI截止至2024年4月30日。纳入了队列研究和随机对照试验（RCT）的数据。结果包括主要结果（再次切除、局部复发、手术切缘阳性、乳房切除术）、次要结果和安全性结果。 Cochrane 偏倚风险评估工具和纽卡斯尔-渥太华量表用于评估结果质量。我们的研究包括 52 项研究，涉及 46,835 名患者。主要结局包括再次切除、局部复发、手术切缘阳性和乳房切除术，OS 与 BCS 相比存在显着差异（RR 0.68 [0.56, 0.82]、RR 0.62 [0.47, 0.82]、RR 0.76 [0.59, 0.98]、 RR 分别为 0.66 [0.44, 0.98]），表明 OS 疗效优越。此外，OS 表现出显着的美学益处（RR 1.17 [1.03, 1.33] 和 RR 1.34 [1.18, 1.52]）。虽然 OS 组的总并发症明显较少（RR 0.70 [0.53, 0.94]），但具体并发症的差异并不显着。此外，亚组分析是根据国籍、样本量、质量和类型进行的。与 BCS 相比，OS 在各个方面都表现出优越或至少相当的结果。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Breast cancer is the most common cancer among women. The surgical treatment of breast cancer has transitioned progressively from radical mastectomy to breast-conserving surgery. In this meta-analysis, we are aiming to compare oncoplastic breast-conserving surgery (OS) with conventional breast-conserving surgery (BCS) in terms of efficacy and safety.We searched Medline, Web of Science, Embase, Cochrane databases, Clinicaltrial.gov, and CNKI until April 30, 2024. Data from cohort studies and randomized controlled trials (RCTs) were included. Outcomes included primary outcomes (re-excision, local recurrence, positive surgical margin, mastectomy), secondary outcomes and safety outcomes. The Cochrane Risk of Bias Assessment Tool and Newcastle-Ottawa Scale were used to evaluate the quality of outcomes.Our study included 52 studies containing 46,835 patients. Primary outcomes comprise re-excision, local recurrence, positive surgical margin, and mastectomy, there were significant differences favoring OS over BCS (RR 0.68 [0.56, 0.82], RR 0.62 [0.47, 0.82], RR 0.76 [0.59, 0.98], RR 0.66 [0.44, 0.98] respectively), indicating superior efficacy of OS. Additionally, OS demonstrated significant aesthetic benefits (RR 1.17 [1.03, 1.33] and RR 1.34 [1.18, 1.52]). While total complications were significantly fewer in the OS group (RR 0.70 [0.53, 0.94]), the differences in specific complications were not significant. Furthermore, subgroup analyses were conducted based on nationality, sample size, quality, and type.OS demonstrates either superior or at least comparable outcomes across various aspects when compared to BCS.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.