糖酵解，肿瘤微环境的甜味食欲。
Glycolysis, The Sweet Appetite of the Tumour Microenvironment.
发表日期：2024 Aug 08
作者：
Zeinab Kooshan, Lilibeth Cárdenas-Piedra, Judith Clements, Jyotsna Batra
来源：
CANCER LETTERS
摘要：
即使在氧气充足的情况下，癌细胞也会表现出代谢表型的改变，其特点是糖酵解和乳酸生成增加，这种现象被称为瓦伯格效应。这种代谢重编程是一种至关重要的适应，使癌细胞能够满足其升高的能量和生物合成需求。重要的是，肿瘤微环境在塑造和维持癌细胞的这种代谢转变方面发挥着关键作用。这篇综述探讨了肿瘤微环境与瓦尔堡效应之间的复杂关系，强调了这个生态位内的通讯如何调节癌细胞代谢并影响肿瘤进展和治疗耐药性。我们讨论了将 Warburg 效应作为一种有前景的治疗策略的潜力，旨在破坏癌细胞的代谢优势，并增强我们对肿瘤微环境中这种复杂相互作用的理解。版权所有 © 2024。由 Elsevier B.V. 出版。
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as the Warburg effect. This metabolic reprogramming is a crucial adaptation that enables cancer cells to meet their elevated energy and biosynthetic demands. Importantly, the tumor microenvironment plays a pivotal role in shaping and sustaining this metabolic shift in cancer cells. This review explores the intricate relationship between the tumor microenvironment and the Warburg effect, highlighting how communication within this niche regulates cancer cell metabolism and impacts tumor progression and therapeutic resistance. We discuss the potential of targeting the Warburg effect as a promising therapeutic strategy, with the aim of disrupting the metabolic advantage of cancer cells and enhancing our understanding of this complex interplay within the tumor microenvironment.Copyright © 2024. Published by Elsevier B.V.