对藤黄果皮的植物化学研究分离出 12 种以前未描述过的具有多种骨架的多环聚异戊二烯酰基间苯三酚 (PPAP, 1-12)。它们的结构通过综合光谱分析、ECD 计算和单晶 X 射线衍射确定。化合物6-9具有罕见的双环[4.3.1]癸烷骨架。此外，还评估了 12 个分离株的抗肿瘤活性。结果表明，化合物5、9和12在多种癌细胞系中表现出显着的细胞毒性，包括人乳腺癌MDA-MB-231细胞、人肺癌A549细胞、人结肠癌SW480细胞和人卵巢癌嘿，细胞。进一步的研究表明，化合物5诱导细胞周期停滞和细胞凋亡，从而抑制MDA-MB-231细胞的生长。总而言之，这些发现扩大了 PPAP 的化学多样性，并进一步证明了 PPAP 作为癌症治疗候选药物的潜力。版权所有 © 2024。由 Elsevier Ltd 出版。

The phytochemical investigation on the pericarps of Garcinia multiflora resulted in the isolation of 12 previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs, 1‒12) with a variety of skeletons. Their structures were determined by comprehensive spectroscopic analyses, ECD calculations, and single-crystal X-ray diffraction. Compounds 6‒9 possess a rare bicyclo[4.3.1]decane skeleton. Additionally, the anti-tumor activity of the 12 isolates was evaluated. The results indicated that compounds 5, 9, and 12 exhibited significant cytotoxicity in a wide range of cancer cell lines, including the human breast cancer MDA-MB-231 cells, human lung cancer A549 cells, human colon cancer SW480 cells and human ovarian cancer HEY cells. Further studies indicated that compound 5 induced cell cycle arrest and apoptosis, to inhibit the growth of MDA-MB-231 cells. Taken together, these findings expand the chemical diversity of PPAPs and further demonstrate the potential of PPAPs as candidates for cancer treatment.Copyright © 2024. Published by Elsevier Ltd.