心血管疾病（CVD）和前列腺癌（PCa）之间存在显着关联，导致高死亡率。本研究评估了美国 (US) 老年（≥ 65 岁）男性中与 CVD 和 PCa 相关的死亡率趋势。该分析利用了疾病控制和预防中心的流行病学研究广泛在线数据 (CDC WONDER) 。对 1999 年至 2019 年的多因死亡档案进行了分析，以确定 CVD 和 PCa 被列为促成死因或根本死因的死亡情况。确定了年份、种族和民族以及地理区域等变量的每 100,000 人的粗死亡率和年龄调整死亡率 (AAMR)。为了评估年度百分比变化 (APC)，采用了 Joinpoint 回归程序。 1999 年的总体 AAMR 为 54.3，2019 年为 34.0。在 1999 年至 2015 年 AAMR 下降后，直到 2019 年，死亡率出现惊人上升。非西班牙裔 (NH) 黑人和非裔美国男性中最高 (74.6)。从地理上看，西部地区（46.3）和非大都市地区（44.6）死亡率最高。 AAMR 排名第 90% 的州是北达科他州、加利福尼亚州、内布拉斯加州、哥伦比亚特区和密西西比州。 1999 年至 2015 年 CVD 和 PCa 相关死亡率下降后，2015 年至 2019 年趋势出现逆转。解决死亡率上升的问题，特别是弱势群体的死亡率上升问题，需要集中注意力并采取有针对性的战略，在未来几年实施必要的保障措施。版权所有 © 2024。由爱思唯尔公司出版。

There is a significant association between cardiovascular diseases (CVD) and prostate cancer (PCa), leading to high mortality. This study evaluates the trends in mortality associated with CVDs and PCa among older (≥ 65 years) men in the United States (US).This analysis utilized the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). The analysis of Multiple Cause of Death Files was carried out from 1999 to 2019 to identify fatalities with CVD and PCa listed as either contributory or underlying causes of death. Crude and age-adjusted mortality rates (AAMRs) per 100,000 populations for variables such as year, race and ethnicity, and geographic regions were determined. To assess annual percent change (APC), a Joinpoint regression program was employed.Overall AAMR was 54.3 in 1999 and 34.0 in 2019. After a decline in AAMR from 1999 to 2015, an alarming rise in mortality was observed until 2019. Mortality rates were highest among Non-Hispanic (NH) Black and African American men (74.6). Geographically, the highest mortalities were witnessed in the West (46.3) and non-metropolitan areas (44.6). States with AAMRs ranking in the 90th percentile were North Dakota, California, Nebraska, the District of Columbia, and Mississippi.After decreasing death rates associated with CVD and PCa from 1999 to 2015, a reversal in the trend was observed from 2015 to 2019. Addressing this increase in death rates, especially among the vulnerable population, requires focused attention and targeted strategies to implement necessary safeguards in the upcoming years.Copyright © 2024. Published by Elsevier Inc.