许多肿瘤更喜欢转移到骨，但潜在的机制仍然难以捉摸。人体骨骼系统具有与其他器官不同的独特物理特性，在指导骨内肿瘤细胞的行为方面发挥着关键作用。了解肿瘤细胞在骨内的物理旅程至关重要。在这篇综述中，我们在骨脉管系统和骨髓生态位中的物理线索如何调节肿瘤细胞的命运的背景下讨论骨转移。我们的目标是从力学生物学的角度激发骨转移的创新诊断和治疗方法。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive. The human skeletal system has unique physical properties, that are distinct from other organs, which play a key role in directing the behavior of tumor cells within bone. Understanding the physical journey of tumor cells within bone is crucial. In this review we discuss bone metastasis in the context of how physical cues in the bone vasculature and bone marrow niche regulate the fate of tumor cells. Our objective is to inspire innovative diagnostic and therapeutic approaches for bone metastasis from a mechanobiological perspective.Copyright © 2024 Elsevier Inc. All rights reserved.