尽管脑胶质瘤病 (GC) 已作为一种独立的肿瘤类型从 WHO 分类中删除，但其广泛的浸润模式可能具有独特的生物学行为。然而，GC 在 2021 年 WHO 分类中的临床意义尚未揭晓。本研究调查了成人型弥漫性胶质瘤患者 GC 的发病率、临床病理学和影像学相关性以及预后意义。对 2005 年至 2021 年间来自同一机构的 1,211 名成人型弥漫性胶质瘤患者进行了回顾性图表和影像学检查。在 1,211 名成人型弥漫性胶质瘤患者中，有 99 名（8.2%）患者患有 GC。 GC患者与非GC患者的分子类型比例存在显着差异（P = 0.017）； IDH 野生型胶质母细胞瘤更常见（77.8% 比 66.5%），而 IDH 突变型星形细胞瘤（16.2% 比 16.9%）和少突胶质细胞瘤（6.1% 比 16.5%）在 GC 患者中比非 GC 患者少见GC。对比增强、坏死、囊性变、出血和 GC 2 型的存在是预测 GC 患者 IDH 突变状态的独立危险因素。在多变量分析以及临床、分子和手术因素中，GC 仍然是 IDH 野生型胶质母细胞瘤患者的独立预后因素（HR = 1.25，P = 0.031）。总体而言，我们的数据表明，尽管 GC 不再被列为 WHO 分类中的一个独特病理实体，但考虑到其临床意义，对 GC 的认识可能至关重要。成人型弥漫性胶质瘤中GC的发生率较高，根据分子类型不同，有GC和无GC的患者所占比例不同。影像学可以在术前预测GC患者的分子类型，并可以帮助临床决策。 GC 的预后作用促进了其在临床环境中的认可。© 2024。作者。

Although gliomatosis cerebri (GC) has been removed as an independent tumor type from the WHO classification, its extensive infiltrative pattern may harbor a unique biological behavior. However, the clinical implication of GC in the context of the 2021 WHO classification is yet to be unveiled. This study investigated the incidence, clinicopathologic and imaging correlations, and prognostic implications of GC in adult-type diffuse glioma patients. Retrospective chart and imaging review of 1,211 adult-type diffuse glioma patients from a single institution between 2005 and 2021 was performed. Among 1,211 adult-type diffuse glioma patients, there were 99 (8.2%) patients with GC. The proportion of molecular types significantly differed between patients with and without GC (P = 0.017); IDH-wildtype glioblastoma was more common (77.8% vs. 66.5%), while IDH-mutant astrocytoma (16.2% vs. 16.9%) and oligodendroglioma (6.1% vs. 16.5%) were less common in patients with GC than in those without GC. The presence of contrast enhancement, necrosis, cystic change, hemorrhage, and GC type 2 were independent risk factors for predicting IDH mutation status in GC patients. GC remained as an independent prognostic factor (HR = 1.25, P = 0.031) in IDH-wildtype glioblastoma patients on multivariable analysis, along with clinical, molecular, and surgical factors. Overall, our data suggests that although no longer included as a distinct pathological entity in the WHO classification, recognition of GC may be crucial considering its clinical significance. There is a relatively high incidence of GC in adult-type diffuse gliomas, with different proportion according to molecular types between patients with and without GC. Imaging may preoperatively predict the molecular type in GC patients and may assist clinical decision-making. The prognostic role of GC promotes its recognition in clinical settings.© 2024. The Author(s).