癌症中的 ac4C RNA 修饰：揭示多方面的作用和有希望的治疗前景。
ac4C RNA modification in Cancer: Unraveling Multifaceted Roles and Promising Therapeutic Horizons.
发表日期：2024 Aug 09
作者：
Wenhao Ouyang, Zhenjun Huang, Keyu Wan, Tiantian Nie, Haizhu Chen, Herui Yao
来源：
CANCER LETTERS
摘要：
RNA 修饰在癌症发展中发挥着至关重要的作用，深刻影响着 RNA 生命周期的各个阶段。这些阶段包括细胞质中的核加工、核输出、剪接和翻译。在RNA修饰中，ac4C RNA修饰，也称为N4-乙酰胞苷，因其在乙酰化过程中的独特作用而脱颖而出。特定蛋白质调节 ac4C RNA 修饰，维持这些变化的动态和可逆性质。本综述探讨了 ac4C RNA 修饰的分子机制和生物学功能。它研究了 ac4C RNA 修饰影响癌症发病机制和进展的复杂方式。此外，该综述还对当前检测 ac4C RNA 修饰的方法进行了综合概述。探索操纵这种修饰的潜在应用为新的治疗策略提供了途径，有可能在未来带来更有效的癌症治疗。版权所有 © 2024。由 Elsevier B.V. 出版。
RNA modifications play a crucial role in cancer development, profoundly influencing various stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export, splicing, and translation in the cytoplasm. Among RNA modifications, the ac4C RNA modification, also known as N4-acetylcytidine, stands out for its unique role in acetylation processes. Specific proteins regulate ac4C RNA modification, maintaining the dynamic and reversible nature of these changes. This review explores the molecular mechanisms and biological functions of ac4C RNA modification. It examines the intricate ways in which ac4C RNA modification influences the pathogenesis and progression of cancer. Additionally, the review provides an integrated overview of the current methodologies for detecting ac4C RNA modification. Exploring the potential applications of manipulating this modification suggests avenues for novel therapeutic strategies, potentially leading to more effective cancer treatments in the future.Copyright © 2024. Published by Elsevier B.V.