男性的可改变危险因素（例如吸烟和饮酒）的患病率较高，导致癌症发病率较高和生存率较低。关于全球男性癌症负担的综合证据（包括按年龄组和国家划分的差异）很少。为了解决这个问题，作者分析了 2022 年男性中的 30 种癌症类型，并对 2050 年进行了预测。2022 年 GLOBOCAN 估计值用于描述全球 185 个国家/地区的男性癌症统计数据。死亡率与发病率 (MIR) 的计算方法是将年龄标准化死亡率除以发病率。2022 年，在老年男性（65 岁及以上；61%）中观察到罕见罕见疾病的高 MIR（表明生存率较差）癌症类型（胰腺癌，91%）和人类发展指数较低的国家（HDI；74%）。 2022 年至 2050 年间，癌症病例预计将从 1030 万增加到 1900 万（≥84%）。死亡人数预计将从 540 万增加到 1,050 万（≥93%），其中 65 岁及以上男性（≥117%）以及低人类发展指数和中等人类发展指数国家/地区的死亡人数增加两倍以上（ ≥160%）。预计工作年龄组 (≥39%) 和人类发展指数极高国家/地区 (≥50%) 的癌症病例和死亡人数将会增加。2022 年，男性之间的癌症病例和死亡人数存在巨大差异，这些是预计到 2050 年将扩大。加强卫生基础设施、提高劳动力质量和获取机会、促进国家和国际合作以及促进全民健康覆盖对于减少癌症差异和确保全球男性癌症公平至关重要。© 2024 作者。 《癌症》由 Wiley periodicals LLC 代表美国癌症协会出版。

Men exhibit higher prevalence of modifiable risk factors, such as smoking and alcohol consumption, leading to greater cancer incidence and lower survival rates. Comprehensive evidence on global cancer burden among men, including disparities by age group and country, is sparse. To address this, the authors analyzed 30 cancer types among men in 2022, with projections estimated for 2050.The 2022 GLOBOCAN estimates were used to describe cancer statistics for men in 185 countries/territories worldwide. Mortality-to-incidence ratios (MIRs) were calculated by dividing age-standardized mortality rates by incidence rates.In 2022, a high MIR (indicating poor survival) was observed among older men (aged 65 years and older; 61%) for rare cancer types (pancreatic cancer, 91%) and in countries with low a Human Development Index (HDI; 74%). Between 2022 and 2050, cancer cases are projected to increase from 10.3 million to 19 million (≥84%). Deaths are projected to increase from 5.4 million to 10.5 million (≥93%), with a greater than two-fold increase among men aged 65 years and older (≥117%) and for low-HDI and medium-HDI countries/territories (≥160%). Cancer cases and deaths are projected to increase among working-age groups (≥39%) and very-high-HDI countries/territories (≥50%).Substantial disparities in cancer cases and deaths were observed among men in 2022, and these are projected to widen by 2050. Strengthening health infrastructure, enhancing workforce quality and access, fostering national and international collaborations, and promoting universal health coverage are crucial to reducing cancer disparities and ensuring cancer equity among men globally.© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.