天然化合物通过不同的机制途径治疗三阴性乳腺癌。
Management of triple-negative breast cancer by natural compounds through different mechanistic pathways.
发表日期：2024
作者：
Mohammed Kaleem, Mandar Thool, Nitin G Dumore, Abdulrasheed O Abdulrahman, Wasim Ahmad, Amal Almostadi, Mohammad Hassan Alhashmi, Mohammad Amjad Kamal, Shams Tabrez
来源：
Frontiers in Genetics
摘要：
三阴性乳腺癌（TNBC）是最严重的乳腺癌，其特征是雌激素、孕激素和人类表皮生长因子受体的丧失。它是由多种遗传和表观遗传因素引起的，导致预后不良。表观遗传变化，例如 DNA 甲基化和组蛋白修饰，是 TNBC 进展和转移的主要机制。这篇综述全面涵盖了 TNBC 的各种亚型及其表观遗传原因。此外，TNBC 与所有与这种癌症进展相关的重要基因和信号通路的遗传关联也已被纳入。此外，还详细讨论了通过不同机制途径使用天然化合物以成功管理 TNBC。版权所有 © 2024 Kaleem、Thool、Dumore、Abdulrahman、Ahmad、Almostadi、Alhashmi、Kamal 和 Tabrez。
Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, the genetic association of TNBC with all significant genes and signaling pathways linked to the progression of this form of cancer has been enlisted. Furthermore, the possible uses of natural compounds through different mechanistic pathways have also been discussed in detail for the successful management of TNBC.Copyright © 2024 Kaleem, Thool, Dumore, Abdulrahman, Ahmad, Almostadi, Alhashmi, Kamal and Tabrez.