经济参与对癌症幸存者健康的影响是显着的。我们的研究旨在探讨胃癌幸存者早期经济活动丧失 (EA) 与全因死亡风险之间的关联。这项回顾性队列研究利用了韩国国民健康保险服务的数据，重点关注 30-59 岁的人群。 2009 年 1 月至 2013 年 12 月期间接受手术或内窥镜手术的老年胃癌患者。主要结局指标是全因死亡率。当患者的保险状态在治疗后一年内转变为受抚养人时，就会发现早期失去 EA。使用多变量 Cox 比例风险模型估算全因死亡率的调整后风险比 (HR) 和 95% 置信区间 (CI)，对手术组和内窥镜组进行单独分析。在 24,159 名患者中（中位随访时间为 9.9 年）， 2976 人 (12.3%) 经历过全因死亡。具体而言，其中 2835 例死亡发生在接受手术的患者中，而 141 例发生在内窥镜手术组中。手术组中 14.4% 的 EA 早期丧失，内窥镜手术组中 7.7% 的早期丧失 EA。与 EA 早期丧失相关的全因死亡率的调整后 HR (95% CI) 手术组为 1.39 (1.27-1.54)，内窥镜手术组为 2.27 (1.46-3.52)。对于接受过胃癌根治性治疗的患者来说，EA 过早丧失以及全因死亡风险增加。它强调了持续 EA 在增强这些幸存者的健康结果方面的关键作用。© 2024。作者获得国际胃癌协会和日本胃癌协会的独家许可。

The impact of economic engagement on the health of cancer survivors is notable. Our study aims to explore the association between early loss of economic activity (EA) and the risk of all-cause mortality among gastric cancer survivors.This retrospective cohort study utilized data from Korea's National Health Insurance Service, focusing on 30-59-year-old gastric cancer patients who received either surgery or endoscopic procedures from January 2009 to December 2013. The primary outcome measure was all-cause mortality. Early loss of EA was identified when a patient's insurance status shifted to dependent within one year following treatment. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for all-cause mortality were estimated using multivariable Cox proportional hazards models, conducting separate analyses for surgical and endoscopic groups.Among 24,159 patients (median follow-up, 9.9 years), 2976 (12.3%) experienced all-cause mortality. Specifically, 2835 of these deaths occurred in patients who underwent surgery, while 141 were in the endoscopic procedure group. Early loss of EA was recorded in 14.4% of the surgery group and 7.7% of the endoscopic procedure group. Adjusted HRs (95% CI) for all-cause mortality associated with early loss of EA were 1.39 (1.27-1.54) for the surgery group and 2.27 (1.46-3.52) for the endoscopic procedure group.This study highlights a significant association between the early loss of EA and an increased risk of all-cause mortality in those who have undergone curative treatments for gastric cancer. It underscores the crucial role of sustaining EA in enhancing the health outcomes of these survivors.© 2024. The Author(s) under exclusive licence to The International Gastric Cancer Association and The Japanese Gastric Cancer Association.