回顾史蒂文-约翰逊综合征 (SJS)/中毒性表皮坏死松解症 (TEN) 的病理生理学、近期生物标志物，并重点介绍近年来发表的重要证据。多项研究揭示了泪液细胞因子与病理成分之间的关​​系在 SJS/10 名患者的眼中。急性期的具体临床特征和相关危险因素已显示出与慢性眼部后遗症显着相关。最近的治疗方案，包括早期脉冲全身和局部类固醇，以及肿瘤坏死因子-α抑制剂，已证明对眼部结果有积极作用。除了传统的手术治疗外，还引入了一种新的手术技术，即简单口腔粘膜上皮移植（SOMET），作为 SJS 患者的简单眼表重建术。知识和管理策略的进步显着提高了 SJS/TEN 的眼部治疗效果眼睛。更深入地了解这些眼睛的生物标志物变化可以促进未来针对性治疗方案的开发。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

To review the pathophysiology, recent biomarkers related to the ocular aspects of Steven-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and to highlight notable evidence published in recent years.Several studies reveal the relationship between tear cytokines and the pathological components in eyes of SJS/TEN patients. Specific clinical features and associated risk factors in the acute stage have shown significant correlations with chronic ocular sequelae. Recent treatment protocols, including early pulse systemic and topical steroids, as well as tumor necrosis factor-α inhibitors, have demonstrated positive effects on ocular outcomes. In addition to conventional surgical treatment, a new surgical technique, simple oral mucosal epithelial transplantation (SOMET), has been introduced as a simple ocular surface reconstruction for patient with SJS.Advancements in knowledge and management strategies have notably enhanced ocular outcomes for SJS/TEN eyes. A deeper understanding of the biomarker changes in these eyes could facilitate the development of future targeted treatment options.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.