抗肿瘤药物的心肌毒性机制和潜在的治疗策略：文献综述。
Mechanisms of myocardial toxicity of antitumor drugs and potential therapeutic strategies: A review of the literature.
发表日期：2024 Aug 10
作者：
Yang Jia, Qihong Wu, Zhigang Yang, Ran Sun, Kun Zhang, Xia Guo, Rong Xu, Yingkun Guo
来源：
CURRENT PROBLEMS IN CARDIOLOGY
摘要：
随着化疗药物的不断开发，在临床应用中取得了良好的效果。然而，心肌毒性是最大的挑战。蒽环类药物、免疫检查点抑制剂、铂类药物应用广泛。靶向药物递送、纳米材料和动态成像评估都是新兴的研究方向。本文回顾了最近关于使用靶向纳米药物递送和成像技术来评估抗肿瘤药物的心肌毒性的文献，并讨论了潜在的机制。版权所有 © 2024。由 Elsevier Inc. 出版。
With the successive development of chemotherapy drugs, good results have been achieved in clinical application. However, myocardial toxicity is the biggest challenge. Anthracyclines, immune checkpoint inhibitors, and platinum drugs are widely used. Targeted drug delivery, nanomaterials and dynamic imaging evaluation are all emerging research directions. This article reviews the recent literature on the use of targeted nanodrug delivery and imaging techniques to evaluate the myocardial toxicity of antineoplastic drugs, and discusses the potential mechanisms.Copyright © 2024. Published by Elsevier Inc.