揭示硫醇生物标志物：谷胱甘肽和半胱胺。
Unveiling thiol biomarkers: Glutathione and cysteamine.
发表日期：2024 Aug 10
作者：
M G Gopika, Surya Gopidas, Gokul S Jayan, P S Arathy, Beena Saraswathyamma
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
谷胱甘肽和半胱胺在糖尿病、癌症、肾衰竭、帕金森病和甲状腺功能减退等一系列疾病中的作用强调了它们的生理和临床重要性。这就需要可访问、快速且具有成本效益的测试，以促进临床诊断和治疗选择。本文研究了用于检测谷胱甘肽和半胱胺的多种技术。讨论的方法包括伏安法和电流分析法等电分析技术，检查其灵敏度和提供实时分析的能力。此外，本研究还研究了气相色谱-质谱法 (GC-MS) 和高效液相色谱法 (HPLC) 在测量谷胱甘肽和半胱胺浓度时的准确性。此外，还强调了基于纳米技术的新方法（例如等离子体纳米粒子和量子点）在提高谷胱甘肽和半胱胺检测灵敏度方面的潜力。版权所有 © 2024。由 Elsevier B.V. 出版。
The physiological and clinical importance of Glutathione and Cysteamine is emphasized by their participation in a range of conditions, such as diabetes, cancer, renal failure, Parkinson's disease, and hypothyroidism. This necessitates the requirement for accessible, expedited, and cost-efficient testing that can facilitate clinical diagnosis and treatment options. This article examines numerous techniques used to detect both glutathione and cysteamine. The discussed methods include electroanalytical techniques such as voltammetry and amperometry, which are examined for their sensitivity and ability to provide real-time analysis. Furthermore, this study investigates the accuracy of gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) in measuring the concentrations of glutathione and cysteamine. Additionally, the potential of new nanotechnology-based methods, such as plasmonic nanoparticles and quantum dots, to improve the sensitivity of detecting glutathione and cysteamine is emphasized.Copyright © 2024. Published by Elsevier B.V.