细胞减灭手术（CRS）和腹腔热腹腔化疗（HIPEC）可能导致显着的发病率和延长住院时间。术后感染是这些并发症的一大负担。本研究旨在评估术后 C 反应蛋白 (CRP) 水平对总体感染并发症和吻合口瘘的预测价值。这是一项单中心前瞻性研究，对象为 2018 年至 2020 年在 Maisonneuve 接受 CRS 和 HIPEC 治疗腹膜转移的患者。加拿大魁北克省蒙特利尔的罗斯蒙特医院。手术后 10 天内每天测量 CRP 水平。对有感染并发症的患者和无感染并发症的患者进行了比较。共纳入99名患者。 30 名患者出现感染并发症（30.3%），4 名患者出现吻合口瘘（4%）。术后第 2-10 天 (POD) 发生感染并发症的患者的 CRP 水平显着升高。每日截止值最准确地预测第 8 天的感染并发症（94.3 mg/L；曲线下面积 [AUC] 0.85，敏感性 [SE] 76.2%，特异性 [SP] 94.7%，阳性预测值 [PPV] 88.9% ，阴性预测值 [NPV] 87.8%；p < 0.0001）和第 9 天（72.7 mg/L；AUC 0.89，SE 95.2%，SP 81.8%，PPV 76.9%，NPV 96.4%；p < 0.0001）。患有感染性并发症的患者手术时间较长，腹膜癌指数较高，肠吻合次数较多，而他们的基线特征具有可比性。CRP 测量有助于预测 CRS 和 HIPEC 后的感染性并发症，特别是在 POD 8 和 9 上。术后第一周后的偏差值更加准确，尤其是在排除感染性并发症方面。© 2024。外科肿瘤学会。

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can be associated with significant morbidity and prolonged hospital stay. Postoperative infections account for a high burden of these complications. This study aimed to assess the predictive value of postoperative C-reactive protein (CRP) levels for overall infectious complications and anastomotic leaks.This was a single-center prospective study of patients undergoing CRS and HIPEC for peritoneal metastases between 2018 and 2020 at Maisonneuve-Rosemont Hospital in Montreal, QC, Canada. CRP levels were measured daily for 10 days following surgery. A comparison was made between patients with infectious complications and those without.Ninety-nine patients were included. Thirty patients had infectious complications (30.3%) and four patients presented an anastomotic leak (4%). CRP levels were significantly higher in patients with infectious complications from postoperative days (PODs) 2-10. Daily cut-off values most accurately predicted infectious complications on day 8 (94.3 mg/L; area under the curve [AUC] 0.85, sensitivity [SE] 76.2%, specificity [SP] 94.7%, positive predictive value [PPV] 88.9%, negative predictive value [NPV] 87.8%; p < 0.0001) and day 9 (72.7 mg/L; AUC 0.89, SE 95.2%, SP 81.8%, PPV 76.9%, NPV 96.4%; p < 0.0001). Patients with infectious complications had longer operative time, higher peritoneal cancer index, and a higher number of intestinal anastomoses, while their baseline characteristics were comparable.Measurement of CRP helps predict infectious complications following CRS and HIPEC, particularly on PODs 8 and 9. Cut-off values are more accurate after the first postoperative week, especially in ruling out infectious complications.© 2024. Society of Surgical Oncology.