热休克蛋白 47 (HSP47) 是一种伴侣蛋白，负责调节胶原蛋白的成熟和运输，直接影响胶原蛋白的合成水平。 HSP47 表达异常或功能障碍与胶原蛋白相关疾病有关，尤其是纤维化。最近的报告揭示了 HSP47 在各种细胞过程中的新功能。 Hsp47 在这些替代作用中的失调与多种疾病有关，例如癌症、自身免疫性和神经退行性疾病，从而凸显了其作为诊断生物标志物和治疗靶点的潜力。在这篇综述中，我们讨论了 HSP47 在人类疾病中的病理生理学作用、其作为诊断工具的潜力、临床筛查技术及其作为治疗干预目标的作用。© 2024 作者。约翰·威利出版的《临床与转化医学》

Heat shock protein 47 (HSP47) is a chaperone protein responsible for regulating collagen maturation and transport, directly impacting collagen synthesis levels. Aberrant HSP47 expression or malfunction has been associated with collagen-related disorders, most notably fibrosis. Recent reports have uncovered new functions of HSP47 in various cellular processes. Hsp47 dysregulation in these alternative roles has been linked to various diseases, such as cancer, autoimmune and neurodegenerative disorders, thereby highlighting its potential as both a diagnostic biomarker and a therapeutic target. In this review, we discuss the pathophysiological roles of HSP47 in human diseases, its potential as a diagnostic tool, clinical screening techniques and its role as a target for therapeutic interventions.© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.