卡波西肉瘤 (KS) 是一种血管增殖性疾病，其病因为病毒，其发病机制是由免疫功能障碍引起的多因素。在受疱疹病毒等潜伏病毒感染影响的患者中，SARS-CoV-2 感染可能会导致宿主细胞裂解周期重新激活。强大的免疫系统反应对于消除病原体和解决潜伏和非潜伏病毒感染至关重要。我们报告了一系列以 SARS-CoV-2 感染后肿瘤进展为特征的 KS 病例。我们对 PubMed/MEDLINE 和 EMBASE 数据库进行了系统的文献综述。关键词包括“SARS-CoV-2”、“HHV-8”、“卡波西肉瘤”、“IL-6”和“COVID-19”。 英语语言受到限制。我们的研究未涵盖的项目被排除在外。 KS 是一种与免疫系统受损有关的复杂疾病。导致暂时或永久性免疫缺陷的病症可能会引发病毒重新激活或加剧现有疾病。 COVID-19 患者细胞因子水平的增加，加上淋巴细胞下调和诱导疱疹病毒裂解性重新激活的治疗，可能有助于 SARS-CoV-2 感染后 KS 的进展。这些观察结果表明，应该在 SARS-CoV-2 感染期间和感染后对 KS 患者进行临床监测。尽管如此，仍应收集前瞻性数据来验证这一假设，并增强我们对 KS 发病或进展机制的理解。© 2024 作者。 《医学病毒学杂志》由 Wiley periodicals LLC 出版。

Kaposi's sarcoma (KS) is an angio-proliferative disease with a viral etiology and a multifactorial pathogenesis that results from immune dysfunction. In patients affected by latent viral infections such as herpesviruses, SARS-CoV-2 infection may result in lytic cycle reactivation in host cells. A robust immune system response is crucial for eliminating pathogens and resolving both latent and non-latent viral infections. We report a case series of KS characterized by tumor progression after SARS-CoV-2 infection. We performed a systematic literature review of the PubMed/MEDLINE and EMBASE databases. The keyword terms included "SARS-CoV-2," "HHV-8," "Kaposi's sarcoma," "IL-6," and "COVID-19." English language restriction was applied. Items not covered by our study were excluded. KS is a complex disease linked to an impaired immune system. Conditions that result in temporary or permanent immunodeficiency can trigger viral reactivation or exacerbate an existing disease. It is feasible that the increase in cytokine levels in COVID-19 patients, coupled with lymphocyte downregulation and treatment that induces herpesvirus lytic reactivation, may contribute to the progression of KS after SARS-CoV-2 infection. These observations suggest that patients with KS should be clinically monitored both during and after SARS-CoV-2 infection. Nevertheless, prospective data should be collected to validate this hypothesis and enhance our understanding of the mechanisms implicated in the onset or progression of KS.© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.