皮肤癌，包括恶性黑色素瘤、基底癌、鳞状细胞癌和默克尔细胞癌，给医疗保健带来了巨大的挑战。手术和化疗等传统治疗方法存在非特异性、毒性和不良反应等局限性。即将到来的治疗以纳米尺寸的输送系统为主，它可以改善治疗效果，同时最大限度地减少副作用。展望未来，靶向纳米颗粒可以在肿瘤部位局部输送药物，确保对周围组织的损害最小。这篇综述探讨了针对特定类型皮肤癌的各种靶向策略。讨论的策略包括纳米载体介导的多种配体（如适体、抗体、肽和维生素）的靶向递送及其在皮肤癌中的优势。会议还详细讨论了智能输送系统、微针辅助输送和三维打印支架等即将到来的尖端技术。本综述中的研究结果总结自 PubMed、Scopus、Web of Science、ClinicalTrials.gov、NIH 等数据库以及 2005 年至 2024 年发表的讨论皮肤癌靶向治疗的文章。特定的癌症靶向策略有望实现个性化治疗，提高疗效率并减少对强化治疗的需求。该评论强调了这个充满活力的领域的各种挑战、解决方案以及经济方面。它进一步强调了专门策略彻底改变皮肤癌治疗的潜力。

Skin carcinoma, including malignant melanoma, basal, squamous, and Merkel cell carcinoma, present significant healthcare challenges. Conventional treatments like surgery and chemotherapy suffer from limitations like non-specificity, toxicity, and adverse effects. The upcoming treatments are dominated by nano-sized delivery systems, which improve treatment outcomes while minimizing side effects. Moving ahead, targeted nanoparticles allow localized delivery of drugs at tumor site, ensuring minimal damage to surrounding tissues.This review explores various targeting strategies for specific types of skin cancers. The strategies discussed include nanocarrier-mediated targeted delivery with multiple types of ligands like aptamers, antibodies, peptides, and vitamins and their advantages in skin cancer. Upcoming cutting-edge technologies such as smart delivery systems, microneedle-assisted delivery and three-dimensional printed scaffolds have also been discussed in detail. The findings in this review are summarized from databases like PubMed, Scopus, Web of Science, ClinicalTrials.gov, NIH, and articles published between 2005 and 2024 that discuss targeted therapy for skin cancer.Specific cancer-targeting strategies promise personalized treatments, improving response rates and reducing need for intensive therapies. The review highlights various challenges, their solution, and economic aspects in this dynamic field. It further emphasizes the potential for specialized strategies to revolutionize skin cancer treatment.