免疫治疗已发展成为现代癌症治疗的重要方式。不幸的是，检查点抑制剂免疫疗法目前是全身给药，需要频繁给药，这可能导致毒性和严重的、有时是致命的不良事件。针对口腔癌和口腔潜在恶性疾病的免疫调节剂的局部递送有望实现最大的治疗潜力并减少全身不良反应。本综述将讨论当前标准护理系统疗法的局限性，并重点介绍用于口腔癌和口腔潜在恶性疾病免疫治疗的局部肿瘤内递送平台的研究进展。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.Copyright © 2024 Elsevier Ltd. All rights reserved.