导致髓母细胞瘤分化结束。
Leading medulloblastoma to a differentiation end.
发表日期：2024 Aug 12
作者：
Carolina Nör, Vijay Ramaswamy
来源：
CANCER CELL
摘要：
事实证明，针对髓母细胞瘤的有效且毒性较小的疗法非常难以捉摸。在本期《癌细胞》中，Yang 等人。表明甲状腺激素治疗通过逆转 EZH2 介导的 NeuroD1 转录抑制，导致神经源性分化因子 1 (NeuroD1) 的激活和髓母细胞瘤细胞的分化。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Effective and less toxic therapies for medulloblastoma have proved to be highly elusive. In this issue of Cancer Cell, Yang et al. show that thyroid hormone treatment leads to the activation of neurogenic differentiation factor 1 (NeuroD1) and differentiation of medulloblastoma cells through reversing EZH2-mediated transcriptional repression of NeuroD1.Copyright © 2024 Elsevier Inc. All rights reserved.