最近的癌症治疗研究发现，基于壳聚糖 (Ch) 的纳米粒子在靶向基因传递方面显示出巨大的潜力。壳聚糖是一种生物相容性和可生物降解的聚合物，具有卓越的特性，使其成为治疗基因的理想载体。这些纳米颗粒可以对 pH、温度和酶等特定刺激做出反应，从而实现基因的精确传递和调控释放。在癌症治疗中，这些纳米粒子已被证明可以有效地将基因传递到肿瘤细胞，从而减缓肿瘤的生长。调整纳米粒子的表面、封装保护剂和使用靶向配体也提高了基因递送效率。基于壳聚糖的智能纳米颗粒已显示出通过选择性释放基因来响应肿瘤状况、增强靶向递送和减少脱靶效应来改善结果的前景。此外，纳米颗粒表面的靶向配体可增加吸收和有效性。尽管需要进一步研究来优化这些纳米粒子的结构和成分并评估其长期安全性，但这些进步为创新的以基因为中心的癌症疗法铺平了道路。版权所有 © 2024。由 Elsevier B.V. 出版。

Recent cancer therapy research has found that chitosan (Ch)-based nanoparticles show great potential for targeted gene delivery. Chitosan, a biocompatible and biodegradable polymer, has exceptional properties, making it an ideal carrier for therapeutic genes. These nanoparticles can respond to specific stimuli like pH, temperature, and enzymes, enabling precise delivery and regulated release of genes. In cancer therapy, these nanoparticles have proven effective in delivering genes to tumor cells, slowing tumor growth. Adjusting the nanoparticle's surface, encapsulating protective agents, and using targeting ligands have also improved gene delivery efficiency. Smart nanoparticles based on chitosan have shown promise in improving outcomes by selectively releasing genes in response to tumor conditions, enhancing targeted delivery, and reducing off-target effects. Additionally, targeting ligands on the nanoparticles' surface increases uptake and effectiveness. Although further investigation is needed to optimize the structure and composition of these nanoparticles and assess their long-term safety, these advancements pave the way for innovative gene-focused cancer therapies.Copyright © 2024. Published by Elsevier B.V.