用于预测免疫检查点抑制反应的空间生物标志物的当前前景。
The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition.
发表日期：2024 Aug 13
作者：
Hannah L Williams, Ana Leni Frei, Thibaud Koessler, Martin D Berger, Heather Dawson, Olivier Michielin, Inti Zlobec
来源：
npj Precision Oncology
摘要：
空间分辨组学技术能够检查组织中的细胞与细胞关系，彻底改变了我们对癌症生物学的看法。临床上，免疫检查点抑制剂（ICI）的开发具有先进的癌症治疗作用。然而，有效实施的一个主要挑战是识别反应的预测生物标志物。在这篇综述中，我们研究了 ICI 反应的空间生物标志物在当前临床基准之外的潜在附加预测价值。© 2024。作者。
Enabling the examination of cell-cell relationships in tissue, spatially resolved omics technologies have revolutionised our perspectives on cancer biology. Clinically, the development of immune checkpoint inhibitors (ICI) has advanced cancer therapeutics. However, a major challenge of effective implementation is the identification of predictive biomarkers of response. In this review we examine the potential added predictive value of spatial biomarkers of response to ICI beyond current clinical benchmarks.© 2024. The Author(s).